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Protein fate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) Histone Methyltransferase (1) HSP (1) Ligands for E3 Ligase (2) mRNA (1) PROTAC Linkers (1)
By Research Areas:	Cancer (6) Neurological Disease (1)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Screening Libraries

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-76701

4-Nitrothalidomide	Drug Derivative	Cancer
4-Nitrothalidomide is a nitrosylated Thalidomide analogue. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

HY-122876

KUNB31	HSP	Cancer
KUNB31 is a selective inhibitor of SP90β with an K_d value of 0.18 μM .

HY-W441376

Thalidomide-1-Me,4-OH	Ligands for E3 Ligase	Cancer
Thalidomide-1-Me,4-OH is a Thalidomide analogue featuring an alcohol. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

HY-W244282

Thalidomide-pinacolborane	Ligands for E3 Ligase	Cancer
Thalidomide-pinacolborane is a Thalidomide analogue featuring a boronic pinacol ester, otherwise known as a Bpin group, and they are most frequently used in Suzuki reactions. This molecule is an activator for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

HY-153421

PRMT5-IN-28	Histone Methyltransferase	Cancer
PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .

HY-W990229

Thalidomide-O-PEG1-OH	PROTAC Linkers	Cancer
Thalidomide-O-PEG1-OH is a PROTAC linker featuring thalidomide with an O-ethyl alcohol. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction. Meanwhile, the hydroxyl is a versatile handle for forming more complex structures through a number of reactions.

HY-174539

Human SOX2 mRNA	mRNA	Neurological Disease
Human SOX2 mRNA encodes the human SRY-box transcription factor 2 (SOX2) protein, a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 involves in the regulation of embryonic development and in the determination of cell fate. In addition, SOX2 is also required for stem-cell maintenance in the central nervous system and could regulate gene expression in the stomach.

Cat. No.	Product Name

HY-L147

Protease Inhibitor Library	796 compounds
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals. Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 796 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

Protease Inhibitor Library

796 compounds

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals.

Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 796 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

HY-L020

Wnt/Hedgehog/Notch Compound Library	517 compounds
The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development. MCE designs a unique collection of 517 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Wnt/Hedgehog/Notch Compound Library

517 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 517 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Cat. No.	Product Name		Classification

HY-174539

Human SOX2 mRNA		mRNA
Human SOX2 mRNA encodes the human SRY-box transcription factor 2 (SOX2) protein, a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 involves in the regulation of embryonic development and in the determination of cell fate. In addition, SOX2 is also required for stem-cell maintenance in the central nervous system and could regulate gene expression in the stomach.

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