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Probe substrate

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-105124A
    Bufuralol hydrochloride
    1 Publications Verification

    Ro 3-4787 hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease Endocrinology
    Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate .
    Bufuralol hydrochloride
  • HY-105124
    Bufuralol
    1 Publications Verification

    Ro 3-4787

    		 Adrenergic Receptor Cardiovascular Disease Endocrinology
    Bufuralol (Ro 3-4787) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate .
    Bufuralol
  • HY-N4194
    Glabrone

    		PPAR Influenza Virus Infection Metabolic Disease
    Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .
    Glabrone
  • HY-118155
    9-Amino-6-chloro-2-methoxyacridine
    2 Publications Verification

    ACMA

    		 Fluorescent Dye Others
    9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
    9-Amino-6-chloro-2-methoxyacridine
  • HY-116862
    Dibenzylfluorescein

    DBF

    		 Cytochrome P450 Fluorescent Dye Others
    Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its Km value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .
    Dibenzylfluorescein
  • HY-131131
    5-CFDA-AM

    		Fluorescent Dye Others
    5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .
    5-CFDA-AM
  • HY-D1079
    EDANS sodium

    		DNA Stain Others
    EDANS sodium is a potent fluorogenic substrates. EDANS sodium is a donor for FRET-based nucleic acid probes and protease substrates. EDANS sodium is often paired with DABCYL or DABSYL. The optimal absorbance and emission wavelengths of EDANS sodium are λabs = 336 nm and λem = 490 nm respectively .
    EDANS sodium
  • HY-P3791
    N-Succinyl-Ile-Ile-Trp-AMC

    		Fluorescent Dye Others
    N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
    N-Succinyl-Ile-Ile-Trp-AMC
  • HY-105124AR
    Bufuralol hydrochloride (Standard)

    Ro 3-4787 hydrochloride (Standard)

    		 Reference Standards Adrenergic Receptor Cardiovascular Disease Endocrinology
    Bufuralol (hydrochloride) (Standard) is the analytical standard of Bufuralol (hydrochloride). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate .
    Bufuralol hydrochloride (Standard)
  • HY-119395
    Kynuramine

    Kynurenamine

    		 Monoamine Oxidase Metabolic Disease
    Kynuramine is an endogenous amine that serves as a fluorescent substrate and probe for plasma amine oxidase .
    Kynuramine
  • HY-119395B
    Kynuramine dihydrochloride

    		Monoamine Oxidase Metabolic Disease
    Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase .
    Kynuramine dihydrochloride
  • HY-D1685
    BZiPAR

    		Fluorescent Dye Others
    BZiPAR is a fluorescent probe. BZiPAR also is a substrate of trypsin that becomes fluorescent after cleavage by the protease .
    BZiPAR
  • HY-D0149
    4-(Trifluoromethyl)umbelliferone

    		Cytochrome P450 Others
    4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes .
    4-(Trifluoromethyl)umbelliferone
  • HY-W614753
    Biotin-naphthylamine

    		Biochemical Assay Reagents Others
    Biotin-naphthylamine is a biotinylated biochemical assay reagent, which is a substrate for ascorbate peroxidase 2 (APEX2). Biotin-naphthylamine is utilized as a novel probe for labeling DNA and RNA .
    Biotin-naphthylamine
  • HY-112080
    BAY-6035

    		Histone Methyltransferase Cancer
    BAY-6035, a chemical probe, is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM .
    BAY-6035
  • HY-D1609
    BODIPY FL Verapamil hydrochloride

    		Fluorescent Dye Others
    BODIPY FL Verapamil hydrochloride is a fluorescent dye, it can be used as a molecular probe to label tissues and cells. BODIPY FL Verapamil hydrochloride is a substrate for both ABCB1 and ABCC1 .
    BODIPY FL Verapamil hydrochloride
  • HY-139912
    Biotin-aniline

    		DNA Stain Biochemical Assay Reagents Others
    Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline is also a novel APEX2 substrate. Biotin-aniline can label proteins via miniSOG. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity .
    Biotin-aniline
  • HY-D1027
    Dansylcadaverine
    Maximum Cited Publications
    12 Publications Verification

    Monodansyl cadaverine

    		 Autophagy Others
    Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands .
    Dansylcadaverine
  • HY-138241
    PBD-BODIPY

    		Fluorescent Dye Others
    PBD-BODIPY is a probe for the spectrophotometric measurement of autoxidation reactions. Co-autoxidation of the PBD-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring loss of absorbance at 591 nm. PBD-BODIPY has been used to measure the activity of radical-trapping antioxidants in cell-free assays. It has also been used as a fluorescent probe for the detection of epoxidation activity.
    PBD-BODIPY
  • HY-D0092
    7-Ethoxy-4-methylcoumarin

    		Cytochrome P450 Others
    7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
    7-Ethoxy-4-methylcoumarin
  • HY-18743
    Coelenterazine
    5 Publications Verification

    		 Reactive Oxygen Species (ROS) Cancer
    Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm) .
    Coelenterazine
  • HY-131838A
    N6-4-aminobutyl-ADP trisodium

    6-AB-ADP trisodium

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    N6-4-aminobutyl-ADP (6-AB-ADP) trisodium is an ADP derivative that can be used as a nucleotide mimetic or coupling agent for labeling enzyme substrates (such as kinases), constructing biological probes, or functionalizing nucleotide chains .
    N6-4-aminobutyl-ADP trisodium
  • HY-108286
    Talinolol

    Cordanum

    		 Adrenergic Receptor Cardiovascular Disease
    Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .
    Talinolol
  • HY-P1230
    HAEGT

    		Dipeptidyl Peptidase GLP Receptor Metabolic Disease
    HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .
    HAEGT
  • HY-149170
    FFN246

    		5-HT Receptor Monoamine Transporter Neurological Disease
    FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation .
    FFN246
  • HY-P2608
    DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH

    		Fluorescent Dye Others
    DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is the substrate for matrix metalloproteinase MMP-1, with a Km of 26.61 μM. DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is utilized as fluorescence probe for detecting protein activity .
    DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH
  • HY-D1341
    Coumberone
    2 Publications Verification

    		 Fluorescent Dye Cancer
    Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .
    Coumberone
  • HY-D0147
    Resorufin pentyl ether

    Pentoxyresorufin

    		 Bacterial Infection
    Resorufin pentyl ether (Pentoxyresorufin) is a Resazurin (HY-111391) analogue. Resorufin pentyl ether can function as a substrate probe to characterize and differentiate between a variety of inducers of cytochromes P-450. Resorufin pentyl ether has bactericidal activity against N. gonorrhoeae .
    Resorufin pentyl ether
  • HY-W076543
    5-(Biotinamido)pentylamine

    		Transglutaminase Others
    5-(Biotinamido)pentylamine is an amine donor substrate for transglutaminase. 5-(Biotinamido)pentylamine can be used as a biotin-labeled probe to specifically participate in the calcium-dependent reaction catalyzed by TG, bind to the γ-carboxamide group of the glutamine residue in the protein, introduce the biotin tag into the target protein, and form a biotinylated protein product. 5-(Biotinamido)pentylamine can be used for the labeling, separation, and detection of TG amine receptor protein substrates .
    5-(Biotinamido)pentylamine
  • HY-D0055
    3-Cyano-7-ethoxycoumarin
    1 Publications Verification

    		 Cytochrome P450 Others
    3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage Target: Cytochrome P450 3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies.
    3-Cyano-7-ethoxycoumarin
  • HY-P10028
    DC432

    		Fluorescent Dye Cancer
    HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inhibit the N-terminal methylation level of NTMT1/2 substrates in HCT116 cells, and is used for the study of NTMT1/2 probes.
    DC432
  • HY-150145
    Cy5-UTP

    		Biochemical Assay Reagents Others
    Cy5-UTP is a substrate for terminal deoxynucleotidyl transferase (TdT). Cy5-UTP can be used to lable RNA probes through in vitro transcription (Excitation/Emission: 650/665 nm). Cy5-labeled mRNA emits orange fluorescence .
    Cy5-UTP
  • HY-P10471
    MPSD

    MARCKS-ED

    		 MARCKS PKC Others
    MPSD (MARCKS-ED) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD can sense membrane curvature and recognize phosphatidylserine. MPSD can be utilized as biological probe to study membrane shape and lipid composition .
    MPSD
  • HY-108286S
    (Rac)-Talinolol-d5

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease
    (Rac)-Talinolol-d5 is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .
    (Rac)-Talinolol-d5
  • HY-110334
    FFN 206 dihydrochloride

    		Fluorescent Dye Others
    FFN 206 dihydrochloride, a fluorescent probe, is used as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. FFN 206 dihydrochloride is capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles .
    FFN 206 dihydrochloride
  • HY-112081
    BAY-707

    		DNA/RNA Synthesis Cancer
    BAY-707, a chemical probe, is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy .
    BAY-707
  • HY-146248
    TFMU-ADPr

    		Poly(ADP-ribose) Glycohydrolase (PARG) Others
    TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .
    TFMU-ADPr
  • HY-D0092R
    7-Ethoxy-4-methylcoumarin (Standard)

    		Reference Standards Cytochrome P450 Others
    7-Ethoxy-4-methylcoumarin (Standard) is the analytical standard of 7-Ethoxy-4-methylcoumarin. This product is intended for research and analytical applications. 7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
    7-Ethoxy-4-methylcoumarin (Standard)
  • HY-100201
    A-196
    5+ Cited Publications

    		 Histone Methyltransferase Cancer
    A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity .
    A-196
  • HY-P10471A
    MPSD TFA

    MARCKS-ED TFA

    		 MARCKS PKC Others
    MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD (HY-P10471). MPSD TFA is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD TFA can sense membrane curvature and recognize phosphatidylserine. MPSD TFA can be utilized as biological probe to study membrane shape and lipid composition .
    MPSD TFA
  • HY-146248A
    TFMU-ADPr triethylamine

    		Poly(ADP-ribose) Glycohydrolase (PARG) Others
    TFMU-ADPr triethylamine is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr triethylamine can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr triethylamine has excellent reactivity, generality, stability, and usability. TFMU-ADPr triethylamine is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .
    TFMU-ADPr triethylamine
  • HY-157486
    KMI169

    		Epigenetic Reader Domain Cancer
    KMI169 is a potent and selective inhibitor targeting lysine methyl-transferase (KMT9) (IC50 = 0.05 μM, Kd = 0.025 μM). KMI169 functions as a bi-substrate inhibitor targeting the cofactor S-5’-adenosyl-L-methionine (SAM) and substrate binding pockets of KMT9. KMI169 can downregulate target genes involved in cell cycle regulation and impair proliferation of tumor cells by inhibiting KMT9. KMI169 is a valuable tool to probe cellular KMT9 functions and can be research for combating diseases including prostate, lung, colon, and invasive bladder cancer .
    KMI169
  • HY-P10471D
    MPSD control peptide

    MARCKS-ED control peptide

    		 MARCKS PKC Others
    MPSD control peptide (MARCKS-ED control peptide) is a control peptide for MPSD peptide (HY-P10471). MPSD (MARCKS-ED) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD can sense membrane curvature and recognize phosphatidylserine. MPSD can be utilized as biological probe to study membrane shape and lipid composition .
    MPSD control peptide
  • HY-W093017
    4-Chloropyridine

    		Amine N-methyltransferase Others
    4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes .
    4-Chloropyridine
  • HY-114209
    MRK-740
    1 Publications Verification

    		 Histone Methyltransferase Cancer
    MRK-740, a chemical probe, is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80?nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50?=?0.8?μM) .
    MRK-740
  • HY-115692
    2-Coumaranone-1-L

    		Fluorescent Dye Others
    2-Coumaranone-1-L serves as a chemiluminescent probe. Under alkaline conditions and in the presence of oxygen, 2-Coumaranone-1-L is capable of undergoing chemiluminescence, which enables its application as a chemiluminescent substrate in biochemical assays. 2-Coumaranone-1-L exhibits its maximum emission wavelength at 442 nm. 2-Coumaranone-1-L is utilized in research within the realm of bioanalysis .
    2-Coumaranone-1-L
  • HY-110210
    BODIPY-FL NHS ester

    BODIPY FL,SE

    		 Fluorescent Dye Others
    BODIPY FL NHS ester (BODIPY FL, SE) is a cell membranes-penatrable amine-reactive fluorescent probe. The maximum excitation/emission wavelength of the BODIPY-FL NHS ester are 502/511 nm, respectively. BODIPY-FL NHS ester has high stability and is insensitive to the polarity, pH and type of solvent, and can maintain stable fluorescence properties under different environmental conditions. BODIPY-FL NHS ester can be used for the synthesis of protease substrates, live cell imaging, protein labeling and immunoassay .
    BODIPY-FL NHS ester
  • HY-W099563
    4-Nitrophenyl stearate

    		Biochemical Assay Reagents Others
    4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.
    4-Nitrophenyl stearate
  • HY-131442
    Alkyne-phenol
    2 Publications Verification

    Alkyne tyramide; Alk-Ph

    		 Biochemical Assay Reagents Others
    Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins . Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-phenol
  • HY-N2464
    Maltotetraose
    1 Publications Verification

    Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose

    		 TNF Receptor Endogenous Metabolite Bacterial Integrin NF-κB Cardiovascular Disease Inflammation/Immunology
    Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases .
    Maltotetraose

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