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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Piezo Channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (2) Piezo Channel (8) Potassium Channel (1) TRP Channel (2) Akt (3) ERK (1) mTOR (2) PI3K (2)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (6) Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Peptides

Targets Recommended: Piezo Channel Chloride Channel Calcium Channel HCN Channel CRAC Channel TRP Channel Sodium Channel Potassium Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18723

Yoda 1 45+ Cited Publications	Piezo Channel Akt ERK Potassium Channel	Cardiovascular Disease
Yoda 1 is a potent and selective *Piezo1* agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca ²⁺ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .

HY-131018

Jedi2 1 Publications Verification	Piezo Channel	Neurological Disease Inflammation/Immunology
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a K_d of 2770??μM .

HY-P1410

GsMTx4 Maximum Cited Publications 58 Publications Verification	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable *mechanosensitive channels* (MSCs) belonging to the Piezo and TRP** channel families. GsMTx4 also blocks cation-selective *stretch-activated channels* (SACs)** , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-P1410A

GsMTx4 TFA Maximum Cited Publications 58 Publications Verification	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable *mechanosensitive channels* (MSCs) belonging to the Piezo and TRP** channel families. GsMTx4 TFA also blocks cation-selective *stretch-activated channels* (SACs)** , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-162501

Yaddle1	Piezo Channel	Inflammation/Immunology
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC₅₀) of 0.40 μM. Yaddle1 can significantly trigger Ca ²⁺ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants .

HY-126010

Dooku1 10+ Cited Publications	Piezo Channel	Others
Dooku1 is a reversibly Yoda1 antagonist with IC₅₀ value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca ²⁺ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research .

HY-P1410B

D-GsMTx4	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel *Piezo2. D-GsMTx4 inhibits [Ca ²⁺]_i* elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

HY-P1410C

D-GsMTx4 TFA	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel *Piezo2. D-GsMTx4 TFA inhibits [Ca ²⁺]_i* elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

Cat. No.	Product Name

HY-L095

Mechanoreceptors Compound Library	289 compounds
Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms. MCE offers a unique collection of 289 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Mechanoreceptors Compound Library

289 compounds

Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms.

MCE offers a unique collection of 289 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Cat. No.	Product Name	Target	Research Area

HY-P1410

GsMTx4 55+ Cited Publications	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable *mechanosensitive channels* (MSCs) belonging to the Piezo and TRP** channel families. GsMTx4 also blocks cation-selective *stretch-activated channels* (SACs)** , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-P1410A

GsMTx4 TFA 55+ Cited Publications	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable *mechanosensitive channels* (MSCs) belonging to the Piezo and TRP** channel families. GsMTx4 TFA also blocks cation-selective *stretch-activated channels* (SACs)** , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-P1410B

D-GsMTx4	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel *Piezo2. D-GsMTx4 inhibits [Ca ²⁺]_i* elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

HY-P1410C

D-GsMTx4 TFA	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel *Piezo2. D-GsMTx4 TFA inhibits [Ca ²⁺]_i* elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

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