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Paradoxical Activation

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175879
    SARM1-IN-7

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-7 is a potent active site (orthosteric) and orally active SARM1 inhibitor. SARM1-IN-7 continuously activates the enzymatic activity of SARM1, thereby exacerbating the depletion of NAD at sub-minimal concentrations. SARM1-IN-7 demonstrated dual benefits in the SARM1-activated cell models and mouse models: a high dose exerted a cell/neuron protective effect, while a low dose exacerbated cell/neuron damage. SARM1-IN-7 can be used for the study of axon degeneration .
    SARM1-IN-7

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