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Pathways Recommended: PROTAC
Results for "

PROTAC α-synuclein degrader

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155021
    PROTAC α-synuclein degrader 5

    		PROTACs α-synuclein Neurological Disease
    PROTAC α-synuclein degrader 5 is a highly selective small-molecule degrader (PROTAC) of α-synuclein aggregates, with a DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research .
    PROTAC α-synuclein degrader 5
  • HY-136001
    PROTAC α-synuclein degrader 3

    		PROTACs α-synuclein Neurological Disease
    PROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research (Pink: target protein ligand (HY-W278021); Black: linker; HY-133302; Blue: E3 ligase VHL ligand (HY-112078)) .
    PROTAC α-synuclein degrader 3
  • HY-157839
    PROTAC α-Synuclein/Tau degrader 1

    		PROTACs α-synuclein Tau Protein Neurological Disease
    PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)) .
    PROTAC α-Synuclein/Tau degrader 1
  • HY-169959
    OTs-PEG3-NHCO-Thalidomide

    		E3 Ligase Ligand-Linker Conjugates Neurological Disease
    OTs-PEG3-NHCO-Thalidomide is a ubiquitin E3 ligase and linker for PROTAC α-synuclein degrader 6 (HY-157839), which can be used in research on neurodegenerative diseases .
    OTs-PEG3-NHCO-Thalidomide

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