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PROTAC α-Synuclein/Tau degrader 1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-157839
    PROTAC α-Synuclein/Tau degrader 1

    		PROTACs α-synuclein Tau Protein Neurological Disease
    PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)) .
    PROTAC α-Synuclein/Tau degrader 1

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