PP 5

By Targets:	Amyloid-β (1) Apoptosis (4) ATM/ATR (1) Biochemical Assay Reagents (1) MAP3K (1) Phosphatase (7) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (7) Neurological Disease (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

Targets Recommended: Calcineurin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108298

Perfluorodecalin PP 5; Perfluorodecahydronaphthalene	Biochemical Assay Reagents	Others
Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears . Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O₂-carrier and used as artificial blood . Perfluorodecalin enhances bone regeneration and cell viability .

HY-155374

PP5-IN-1	Phosphatase Apoptosis	Cancer
PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer .

HY-RS11032

PPP5C Human Pre-designed siRNA Set A PP5; PPT; PPP5	Small Interfering RNA (siRNA)	Others
PPP5C Human Pre-designed siRNA Set A contains three designed siRNAs for PPP5C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP5C Human Pre-designed siRNA Set A PPP5C Human Pre-designed siRNA Set A

HY-RS14428

TFPI2 Human Pre-designed siRNA Set A PP5; REF1; TFPI-2	Small Interfering RNA (siRNA)	Others
TFPI2 Human Pre-designed siRNA Set A contains three designed siRNAs for TFPI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFPI2 Human Pre-designed siRNA Set A TFPI2 Human Pre-designed siRNA Set A

HY-169002

PP5-IN-2	Phosphatase	Cancer
PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC₅₀ value of 0.9 μM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model .

HY-RS18411

Tfpi2 Mouse Pre-designed siRNA Set A PP5/TFPI-2	Small Interfering RNA (siRNA)	Others
Tfpi2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfpi2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tfpi2 Mouse Pre-designed siRNA Set A Tfpi2 Mouse Pre-designed siRNA Set A

HY-152247

DDO3711	MAP3K	Cancer
DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC₅₀ =164.1 nM) not ASK2 (IC₅₀>20 μM). DDO3711 significantly dephosphorylates p-ASK1 ^T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research .

HY-169013

DDO-3733	Phosphatase	Others
DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates .

HY-N6785

Okadaic acid	Phosphatase Apoptosis	Neurological Disease Cancer
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits *PP1* (IC₅₀=15-50 nM), *PP3* (IC₅₀=3.7-4 nM), *PP4* (IC₅₀=0.1 nM), *PP5* (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation .

HY-N6785A

Okadaic acid sodium	Phosphatase Apoptosis	Neurological Disease Cancer
Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits *PP1* (IC₅₀=15-50 nM), *PP3* (IC₅₀=3.7-4 nM), *PP4* (IC₅₀=0.1 nM), *PP5* (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation .

HY-115760

Okadaic acid ammonium salt	Phosphatase	Neurological Disease Cancer
Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for *PP2A* (IC₅₀=0.1-0.3 nM), and inhibits *PP1* (IC₅₀=15-50 nM), *PP3* (IC₅₀=3.7-4 nM), *PP4* (IC₅₀=0.1 nM), *PP5* (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation .

HY-103241

Ro 90-7501 3 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6785

Okadaic acid	Structural Classification Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits *PP1* (IC₅₀=15-50 nM), *PP3* (IC₅₀=3.7-4 nM), *PP4* (IC₅₀=0.1 nM), *PP5* (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71358

	TFPI2 Protein, Human (HEK293, His) Tissue Factor Pathway Inhibitor 2; TFPI-2; Placental Protein 5; PP5; TFPI2	Human	HEK293
	The critical role of the TFPI2 protein in regulating plasmin-mediated matrix remodeling suggests its involvement in extracellular matrix dynamics. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weak factor Xa, affecting coagulation and fibrinolysis. TFPI2 Protein, Human (HEK293, His) is the recombinant human-derived TFPI2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71358A

	TFPI2 Protein, Human (HEK293, C-His) 1 Publications Verification Tissue Factor Pathway Inhibitor 2; TFPI-2; Placental Protein 5; PP5; TFPI2	Human	HEK293
	The critical role of the TFPI2 protein in regulating plasmin-mediated matrix remodeling suggests its involvement in extracellular matrix dynamics. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weak factor Xa, affecting coagulation and fibrinolysis. TFPI2 Protein, Human (HEK293, C-His) is the recombinant human-derived TFPI2 protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85456

	PP5 Antibody (YA5148) PPP5C; PPP5; Serine/threonine-protein phosphatase 5; PP5; Protein phosphatase T; PP-T; PPT	WB	Human, Mouse, Rat

HY-P85519

	PP5 Antibody (YA5211) FLJ36922; FLJ55954; OTTHUMP00000165834; PP-T; PP5; PPP5; PPP5_HUMAN; PPP5C; PPT; Protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/threonine protein phosphatase 5; Serine/threonine-protein phosphatase 5.	WB	Human

HY-P81324

	PPP5C Antibody (YA1069) FLJ36922; FLJ55954; OTTHUMP00000165834; PP-T; PP5; PPP5; PPP5_HUMAN; PPP5C; PPT; Protein phosphatase 5; catalytic subunit; Protein phosphatase T; Serine/threonine protein phosphatase 5; Serine/threonine-protein phosphatase 5.	WB	Human
	PPP5C Antibody (YA1069) is a non-conjugated IgG2a antibody, targeting PPP5C, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). PPP5C Antibody (YA1069) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS11032

PPP5C Human Pre-designed siRNA Set A PP5; PPT; PPP5		siRNAs Human Pre-designed siRNA Sets
PPP5C Human Pre-designed siRNA Set A contains three designed siRNAs for PPP5C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14428

TFPI2 Human Pre-designed siRNA Set A PP5; REF1; TFPI-2		siRNAs Human Pre-designed siRNA Sets
TFPI2 Human Pre-designed siRNA Set A contains three designed siRNAs for TFPI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18411

Tfpi2 Mouse Pre-designed siRNA Set A PP5/TFPI-2		siRNAs Mouse Pre-designed siRNA Sets
Tfpi2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfpi2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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