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Isoforms Recommended:	PKD3

Results for "

PKD3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) HDAC (1) IKK (3) Interleukin Related (3) LRRK2 (3) NF-κB (3) P-glycoprotein (3) Pim (3) PKD (13) Reference Standards (1) Small Interfering RNA (siRNA) (3) TNF Receptor (3)
By Research Areas:	Cancer (8) Cardiovascular Disease (3) Inflammation/Immunology (6)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118052

BPKDi	PKD HDAC	Cardiovascular Disease
BPKDi is an inhibitor of *PKD. BPKDi inhibits three members of the PKD* family, *PKD1, PKD2, and PKD3, with IC₅₀* values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells .

HY-12239

CID755673 5+ Cited Publications	PKD	Cancer
CID755673 is a potent *PKD* inhibitor with IC₅₀s of 182 nM, 280 nM and 227 nM for *PKD1, PKD2* and *PKD3*, respectively.

HY-15698A

CRT0066101 dihydrochloride 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 dihydrochloride is a potent and orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively . CRT0066101 dihydrochloride is also a potent PIM2* inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[3].

HY-15698

CRT0066101 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 is a potent and orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively . CRT0066101 is also a potent PIM2* inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[3].

HY-151374

3-IN-PP1	PKD	Cancer
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC₅₀ values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer .

HY-15528

kb NB 142-70 2 Publications Verification	PKD	Cancer
kb NB 142-70 is a potent *PKD* inhibitor, with IC₅₀s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

HY-112547

CRT5 CRT0066051	PKD	Others
CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of *PKD* in endothelial cells treated with VEGF (IC₅₀s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis .

HY-13454

CID 2011756	PKD	Cancer
CID 2011756 is an ATP competitive *PKD* inhibitor, with an IC₅₀ of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC₅₀, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

HY-15698B

CRT0066101 trihydrochloride	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 (HY-15698). CRT0066101 trihydrochloride is an orally active *PKD* inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for *PKD1, PKD2, and PKD3, respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2* with an IC₅₀ of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects ^[3].

HY-15528R

kb NB 142-70 (Standard)	PKD	Cancer
kb NB 142-70 (Standard) is the analytical standard of kb NB 142-70. This product is intended for research and analytical applications. kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

HY-13687A

IKK 16 hydrochloride Maximum Cited Publications 20 Publications Verification	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting *PKD1, PKD2, and PKD3* with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway ^[3] .

HY-13687

IKK 16 Maximum Cited Publications 20 Publications Verification	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway ^[3] .

HY-13687R

IKK 16 (Standard)	IKK LRRK2 Reference Standards P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Inflammation/Immunology
IKK 16 (Standard) is the analytical standard of IKK 16. This product is intended for research and analytical applications. IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.

HY-RS11149

Prkd3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prkd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prkd3 Mouse Pre-designed siRNA Set A Prkd3 Mouse Pre-designed siRNA Set A

HY-RS11148

PRKD3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRKD3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRKD3 Human Pre-designed siRNA Set A PRKD3 Human Pre-designed siRNA Set A

HY-RS05270

GANAB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GANAB Human Pre-designed siRNA Set A contains three designed siRNAs for GANAB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GANAB Human Pre-designed siRNA Set A GANAB Human Pre-designed siRNA Set A

Prkd3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prkd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRKD3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKD3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GANAB Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GANAB Human Pre-designed siRNA Set A contains three designed siRNAs for GANAB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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