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Isoforms Recommended: PKD1
Results for "

PKD1

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

1

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118052
    BPKDi

    		PKD HDAC Cardiovascular Disease
    BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells [1].
    BPKDi
  • HY-12239
    CID755673
    5+ Cited Publications

    		 PKD Cancer
    CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.
    CID755673
  • HY-131962A
    PKD-IN-1 dihydrochloride

    		PDK-1 Metabolic Disease Cancer
    PKD-IN-1 dihydrochloride (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as PKD-1 inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research [1].
    PKD-IN-1 dihydrochloride
  • HY-RS00002
    Pkd1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) PKD Others

    Pkd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pkd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pkd1 Mouse Pre-designed siRNA Set A
    Pkd1 Mouse Pre-designed siRNA Set A
  • HY-RS00004
    Pkd1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) PKD Others

    Pkd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pkd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pkd1 Rat Pre-designed siRNA Set A
    Pkd1 Rat Pre-designed siRNA Set A
  • HY-RS00003
    PKD1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) PKD Others

    PKD1 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PKD1 Human Pre-designed siRNA Set A
    PKD1 Human Pre-designed siRNA Set A
  • HY-RS00006
    PKD1L2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PKD1L2 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD1L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PKD1L2 Human Pre-designed siRNA Set A
    PKD1L2 Human Pre-designed siRNA Set A
  • HY-RS00007
    PKD1L3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PKD1L3 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD1L3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PKD1L3 Human Pre-designed siRNA Set A
    PKD1L3 Human Pre-designed siRNA Set A
  • HY-RS00005
    PKD1L1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PKD1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for PKD1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PKD1L1 Human Pre-designed siRNA Set A
    PKD1L1 Human Pre-designed siRNA Set A
  • HY-131962
    PKD-IN-1

    		PKD Metabolic Disease Cancer
    PKD-IN-1 (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as PKD-1 inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research [1].
    PKD-IN-1
  • HY-15698
    CRT0066101
    3 Publications Verification

    		 PKD Pim Apoptosis Inflammation/Immunology Cancer
    CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] .
    CRT0066101
  • HY-15698A
    CRT0066101 dihydrochloride
    3 Publications Verification

    		 PKD Pim Apoptosis Inflammation/Immunology Cancer
    CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] .
    CRT0066101 dihydrochloride
  • HY-172944
    GPR40 Activator 3

    		Free Fatty Acid Receptor Metabolic Disease
    GPR40 Activator 3 (compound SC) is a potent GPR40 activator. GPR40 Activator 3 mitigates pulmonary fibrosis by inhibiting M2 macrophage polarization via the GPR40/PKD1/CD36 axis [1].
    GPR40 Activator 3
  • HY-15698B
    CRT0066101 trihydrochloride

    		PKD Pim Apoptosis Inflammation/Immunology Cancer
    CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 (HY-15698). CRT0066101 trihydrochloride is an orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2 with an IC50 of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects [1] .
    CRT0066101 trihydrochloride
  • HY-151374
    3-IN-PP1

    		PKD Cancer
    3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer [1].
    3-IN-PP1
  • HY-15528
    kb NB 142-70
    2 Publications Verification

    		 PKD Cancer
    kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
    kb NB 142-70
  • HY-112547
    CRT5

    CRT0066051

    		 PKD Others
    CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis [1].
    CRT5
  • HY-128142
    PKC/PKD-IN-1

    		PKD PKC Cardiovascular Disease
    PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure [1].
    PKC/PKD-IN-1
  • HY-13454
    CID 2011756

    		PKD Cancer
    CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
    CID 2011756
  • HY-15528R
    kb NB 142-70 (Standard)

    		PKD Cancer
    kb NB 142-70 (Standard) is the analytical standard of kb NB 142-70. This product is intended for research and analytical applications. kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
    kb NB 142-70 (Standard)
  • HY-117051
    STA-2842

    		HSP Cancer
    STA-2842 is an inhibitor of heat shock protein HSP90 with potential to inhibit autosomal dominant polycystic kidney disease (ADPKD). ADPKD is caused by inherited mutations in the PKD1 or PKD2 genes that abnormally activate multiple signaling proteins and pathways that regulate cell proliferation. STA-2842 can significantly reduce initial renal cyst formation and kidney growth in mice, and slow disease progression in mice with existing cysts.
    STA-2842
  • HY-173062
    BRD4 Inhibitor-40

    		Epigenetic Reader Domain c-Myc Others
    BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models [1].
    BRD4 Inhibitor-40
  • HY-13687A
    IKK 16 hydrochloride
    Maximum Cited Publications
    21 Publications Verification

    		 IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related Cardiovascular Disease Inflammation/Immunology
    IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway [1] .
    IKK 16 hydrochloride
  • HY-13687
    IKK 16
    Maximum Cited Publications
    21 Publications Verification

    		 IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related Cardiovascular Disease Inflammation/Immunology
    IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway [1] .
    IKK 16
  • HY-13687R
    IKK 16 (Standard)

    		IKK LRRK2 Reference Standards P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related Inflammation/Immunology
    IKK 16 (Standard) is the analytical standard of IKK 16. This product is intended for research and analytical applications. IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.
    IKK 16 (Standard)
  • HY-RS11145
    Prkd1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) PKC Others

    Prkd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Prkd1 Mouse Pre-designed siRNA Set A
    Prkd1 Mouse Pre-designed siRNA Set A

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