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PI3Kα-IN-27

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178812
    PI3Kα-IN-27

    		PI3K PAK mTOR PERK Apoptosis Cancer
    PI3Kα-IN-27 (Compound 50b) is an orally active PI3K-α inhibitor, with an IC50 of 40 nM. PI3Kα-IN-27 effectively inhibits PAK3, p110α, phospho-mTOR and phospho-ERK1/2. PI3Kα-IN-27 induces early Apoptosis. PI3Kα-IN-27 shows anticancer activity against pancreatic cancer, lung cancer, breast cancer .
    PI3Kα-IN-27

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