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Results for "

PH 6.5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (3) Biochemical Assay Reagents (3) Drug Derivative (1) Fluorescent Dye (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) Liposome (1) MMP (1) Proton Pump (5) Reference Standards (1) Sodium Channel (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (8) Endocrinology (3) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Pegylated Lipids (1) Adjuvant (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: GPR65 RPE65 HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

HY-W440995

DOPE-PEG-Mal (MW 2000)	Liposome	Cancer
DOPE-PEG-Mal (MW 2000) is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.

HY-15295

Vonoprazan Fumarate Maximum Cited Publications 6 Publications Verification TAK-438	Proton Pump	Metabolic Disease Cancer
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-160764

N6-Carboxymethyl-ATP	Drug Derivative	Others
N6-Carboxymethyl-ATP is the alkylation product of ATP with iodoacetic acid at pH 6.5, where alkylation of ATP with iodoacetic acid at pH 6.5 yielded 1-carboxymethyl-ATP which, after alkaline rearrangement gave N6-carboxymethyl-ATP .

HY-159093

Antitumor agent-178	Others	Cancer
GSCs-IN-1 (compound 4 h) is a potent and selective GSCs inhibitor. GSCs-IN-1 has the potential for the research of cancer .

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

HY-120742

MMG-0358	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC₅₀ values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4 .

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dye	Others
Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .

HY-100007A

Vonoprazan hydrochloride TAK-438 hydrochloride	Proton Pump Bacterial	Infection Endocrinology Cancer
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori .

HY-D2763

BP Fluor 532 maleimide	Fluorescent Dye	Others
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

HY-159743

M101	Toll-like Receptor (TLR)	Inflammation/Immunology
M101 is a vaccine adjuvant. Its main component is highly purified immunologically active substances with a pH value ranging from 4.0 to 6.5. This adjuvant is safe, non-toxic and metabolizable, and can effectively induce immune responses in the body. It has strong immune effects on both T-cell-dependent and T-cell-independent antigens. This adjuvant is applicable to various veterinary vaccines and is recommended for use in porcine circovirus.

HY-100007

Vonoprazan Maximum Cited Publications 6 Publications Verification TAK-438 free base	Proton Pump Bacterial	Endocrinology Cancer
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .

HY-Z3421S

Vonoprazan-d3 fumarate	Isotope-Labeled Compounds	Others
Vonoprazan-d₃ fumarate is the deuterium labeled Vonoprazan fumarate (HY-15295). Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-W144703

Heptadecan-9-amine 9-Aminoheptadecane	Biochemical Assay Reagents	Others
Heptadecan-9-amine (9-Aminoheptadecane) is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.

HY-15295R

Vonoprazan Fumarate (Standard)	Proton Pump	Metabolic Disease Cancer
Vonoprazan (Fumarate) (Standard) is the analytical standard of Vonoprazan (Fumarate). This product is intended for research and analytical applications. Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-W800679

Mal-Cyclohexyl-PEG3-Biotin	Biochemical Assay Reagents	Others
Mal-Cyclohexyl-PEG3-Biotin is a PEG linker containing a maleimide moiety and a biotin group. Maleimides react specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The biotinylation can react with amine molecules in the presence of activator EDC or HATU. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein. The PEG moiety also increases solubility of Biotin-PEG conjugates considerably.

HY-100007R

Vonoprazan (Standard) TAK-438 (Standard)	Reference Standards Proton Pump Bacterial	Endocrinology
Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .

HY-113621B

Ageladine A dihydrochloride	Fluorescent Dye MMP	Cancer
Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC₅₀ values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values .

Cat. No.	Product Name	Type

HY-W998680

Fluorescein-maleimide 5-FITC-Maleimide	Fluorescent Dyes/Probes
Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .

HY-D2763

BP Fluor 532 maleimide	Fluorescent Dyes/Probes
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

BP Fluor 532 maleimide

Fluorescent Dyes/Probes

BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

Cat. No.	Product Name	Type

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5	Buffer Reagents
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

Sodium Citrate Buffer, 0.5M, pH 6.5

Buffer Reagents

Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

Cat. No.	Product Name	Target	Research Area

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

Cat. No.	Product Name	Chemical Structure

HY-Z3421S

Vonoprazan-d3 fumarate
Vonoprazan-d₃ fumarate is the deuterium labeled Vonoprazan fumarate (HY-15295). Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

Vonoprazan-d3 fumarate

Vonoprazan-d₃ fumarate is the deuterium labeled Vonoprazan fumarate (HY-15295). Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

Cat. No.	Product Name		Classification

HY-W440995

DOPE-PEG-Mal (MW 2000)		Pegylated Lipids
DOPE-PEG-Mal (MW 2000) is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.

HY-159743

M101		Adjuvant
M101 is a vaccine adjuvant. Its main component is highly purified immunologically active substances with a pH value ranging from 4.0 to 6.5. This adjuvant is safe, non-toxic and metabolizable, and can effectively induce immune responses in the body. It has strong immune effects on both T-cell-dependent and T-cell-independent antigens. This adjuvant is applicable to various veterinary vaccines and is recommended for use in porcine circovirus.

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