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PD-M6

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176166
    PD-M6

    		mTOR PROTACs Cancer
    PD-M6 is an mTOR PROTAC degrader (DC50: 4.8 μM). PD-M6 promotes the ubiquitination and degradation of mTOR. PD-M6 inhibits the proliferation of HeLa, MCF-7, and HepG2 cancer cell lines (IC50 values of 11.3, 2.58, and 3.23 μM, respectively) and induces autophagy. PD-M6 specifically induces the degradation of LAMTOR1, a key protein in the mTOR signaling pathway. (Pink: target protein mTOR ligand (HY-B0795); target protein mTOR ligand activity control (HY-W150930); black: linker (HY-W008296); blue: E3 ligase CRBN ligand (HY-41547); target protein ligand activity control + linker (HY-176167)) .
    PD-M6
  • HY-W150930
    mTOR ligand 1

    		Ligands for Target Protein for PROTAC Cancer
    mTOR ligand 1 (compound T2) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). mTOR ligand 1 can serve as an active control for the target protein ligand of PD-M6 (HY-176166) .
    mTOR ligand 1
  • HY-176167
    mTOR ligand 1-C6-amino

    		Ligands for Target Protein for PROTAC Cancer
    mTOR ligand 1-C6-amino is a conjugate of a target protein ligand (HY-B0795) and a linker (HY-W008296). mTOR ligand 1-C6-amino can be used to synthesize PROTAC PD-M6 (HY-176166) .
    mTOR ligand 1-C6-amino

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