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Results for "

ONOO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Beta-secretase (2) Biochemical Assay Reagents (1) Cholinesterase (ChE) (2) EBV (2) Fluorescent Dye (9) Fungal (1) NF-κB (2) NO Synthase (3) Reactive Oxygen Species (3) Xanthine Oxidase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120380

FeTMPyP	Autophagy	Inflammation/Immunology
FeTMPyP is an orally active peroxynitrite (ONOO ) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits .

HY-N0649

Narcissin 1 Publications Verification Narcissoside	EBV	Neurological Disease Cancer
Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO ^- and SIN-1-derived ONOO ^- with IC₅₀s of 3.5 and 9.6 μM, respectively .

HY-D2479

DMANI	Fluorescent Dye	Metabolic Disease
DMANI is an intramolecular charge transfer (ICT)-based mitochondria-targeted ratiometric fluorescent probe. DMANI can monitor mitochondrial peroxynitrite (ONOO ⁻) in living cells .

HY-130013

HKYellow-AM (6/12-mixture)	Fluorescent Dye	Others
HKYellow-AM (6/12-mixture) is a yellow fluorescent probe that can detect ONOO- in living cells and tissues with high selectivity and sensitivity without cytotoxicity .

HY-D1148

HKGreen-4I 1 Publications Verification	Fluorescent Dye	Others
HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of ONOO ^- in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-D2286

HBT-Fl-BnB	Fluorescent Dye	Others
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

HY-152103

CB2-H	Fluorescent Dye	Others
CB2-H is a dual-channel fluorescent probe for the simultaneous detection of HOCl and ONOO ^-. CB2-H enables the concurrent detection of HOCl and ONOO ^- at two independent channels without spectral cross-interference and can be applied for dual-channel fluorescence imaging of endogenously produced HOCl and ONOO ^- in living cells and zebrafish under different stimulants .

HY-N0649R

Narcissin (Standard)	EBV	Neurological Disease Cancer
Narcissin (Standard) is the analytical standard of Narcissin. This product is intended for research and analytical applications. Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO-?and SIN-1-derived ONOO- with IC50s?of 3.5 and 9.6 μM, respectively .

HY-141508

Flazin	Xanthine Oxidase NO Synthase	Neurological Disease Metabolic Disease Inflammation/Immunology
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits *peroxynitrite (ONOO* ^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀** value of 71.99 μM for ONOO ^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .

HY-161502

DHX-SP	Fluorescent Dye	Others
DHX-SP is a fluorescent probe, which visualizes superoxide anion (O₂ ^·–) and peroxynitrite (ONOO ^–) during ferroptosis of PC12 cells and in the Parkinson’s disease model .

HY-N1650

Pygenic acid B 2α,3α,24-Trihydroxyurs-12-en-28-oic acid	Fungal	Infection
Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity .

HY-N1980

3'-Hydroxypuerarin	Reactive Oxygen Species	Inflammation/Immunology
3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO•, total ROS scavenging activities .

HY-149203

MQA-P	Fluorescent Dye	Others
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

HY-149203A

MQA-P TFA	Fluorescent Dye	Others
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO ^-, λ_em=645 nm; and NIR channel at λ_em>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

HY-N1980R

3'-Hydroxypuerarin (Standard)	Reactive Oxygen Species	Inflammation/Immunology
3'-Hydroxypuerarin (Standard) is the analytical standard of 3'-Hydroxypuerarin. This product is intended for research and analytical applications. 3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO?, total ROS scavenging activities .

HY-D0146

Resorufin benzyl ether BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone	Fluorescent Dye	Others
Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO ^- detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm .

HY-P1956

Human serum albumin 2 Publications Verification HSA	NF-κB NO Synthase	Cardiovascular Disease Inflammation/Immunology Cancer
Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-N0226

Epiberberine	Cholinesterase (ChE) Beta-secretase	Neurological Disease Metabolic Disease
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

HY-N0226A

Epiberberine chloride 4 Publications Verification	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species	Neurological Disease Metabolic Disease
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

HY-153006

2,7-Dichlorodihydrofluorescein 5 Publications Verification DCFH2	Biochemical Assay Reagents	Others
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H₂O₂, ONOO ^-, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) HSA (Cell culture grade, Endotoxin<0.125 EU/mg)	NF-κB NO Synthase	Cardiovascular Disease Inflammation/Immunology
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Cat. No.	Product Name	Type

HY-D2479

DMANI	Fluorescent Dyes/Probes
DMANI is an intramolecular charge transfer (ICT)-based mitochondria-targeted ratiometric fluorescent probe. DMANI can monitor mitochondrial peroxynitrite (ONOO ⁻) in living cells .

HY-130013

HKYellow-AM (6/12-mixture)	Fluorescent Dyes/Probes
HKYellow-AM (6/12-mixture) is a yellow fluorescent probe that can detect ONOO- in living cells and tissues with high selectivity and sensitivity without cytotoxicity .

HY-D1148

HKGreen-4I 1 Publications Verification	Fluorescent Dyes/Probes
HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of ONOO ^- in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

HY-D2286

HBT-Fl-BnB	Fluorescent Dyes/Probes
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

HY-149203

MQA-P	Fluorescent Dyes/Probes
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

MQA-P

Fluorescent Dyes/Probes

MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

HY-D0146

Resorufin benzyl ether BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone	Dyes
Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO ^- detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm .

Cat. No.	Product Name	Type

HY-P1956

Human serum albumin 2 Publications Verification HSA	Native Proteins
Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Human serum albumin

2 Publications Verification

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) HSA (Cell culture grade, Endotoxin<0.125 EU/mg)	Native Proteins
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

HSA (Cell culture grade, Endotoxin<0.125 EU/mg)

Native Proteins

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Narcissin 1 Publications Verification Narcissoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids Annona muricata Linn. Leguminosae Phenols Polyphenols Annonaceae Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	EBV
Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO ^- and SIN-1-derived ONOO ^- with IC₅₀s of 3.5 and 9.6 μM, respectively .

3'-Hydroxypuerarin	Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Reactive Oxygen Species
3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO•, total ROS scavenging activities .

Epiberberine chloride 4 Publications Verification	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

Narcissin (Standard)	Flavonols Structural Classification Flavonoids Annona muricata Linn. Leguminosae Source classification Phenols Polyphenols Plants Annonaceae Glycyrrhiza uralensis Fisch.	EBV
Narcissin (Standard) is the analytical standard of Narcissin. This product is intended for research and analytical applications. Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO-?and SIN-1-derived ONOO- with IC50s?of 3.5 and 9.6 μM, respectively .

Flazin	Simaroubaceae Source classification Plants Indole Alkaloids Brucea javanica (L.) Merr.	Xanthine Oxidase NO Synthase
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits *peroxynitrite (ONOO* ^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀** value of 71.99 μM for ONOO ^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .

Pygenic acid B 2α,3α,24-Trihydroxyurs-12-en-28-oic acid	Infection Triterpenes Classification of Application Fields Actinidia chinensis Planch. Terpenoids Source classification Plants Actinidiaceae Disease Research Fields	Fungal
Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity .

3'-Hydroxypuerarin (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Isoflavones	Reactive Oxygen Species
3'-Hydroxypuerarin (Standard) is the analytical standard of 3'-Hydroxypuerarin. This product is intended for research and analytical applications. 3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO?, total ROS scavenging activities .

Epiberberine	Alkaloids Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids	Cholinesterase (ChE) Beta-secretase
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

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