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Results for "

OCA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminotransferases (Transaminases) (1) Endogenous Metabolite (1) FXR (3) HPPD (2) Reference Standards (1) Small Interfering RNA (siRNA) (1) TGF-β Receptor (1)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0607

Nitisinone 2 Publications Verification NTBC; Nitisone; SC0735	HPPD	Metabolic Disease
Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-153114

HEC96719	FXR	Inflammation/Immunology
HEC96719 is a selective and orally active tricyclic farnesoid X receptor (FXR) agonist with EC₅₀ values of 1.37 and 1.55 nM by time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively. HEC96719 significantly improves non-alcoholic steatohepatitis (NASH) and liver fibrosis with favorable tissue distribution in liver and intestine. HEC96719 can be used for the research of non-alcoholic steatohepatitis .

HY-RS09739

OCA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OCA2 Human Pre-designed siRNA Set A contains three designed siRNAs for OCA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OCA2 Human Pre-designed siRNA Set A OCA2 Human Pre-designed siRNA Set A

HY-139636

MCA17-1	TGF-β Receptor	Others
MCA17-1 shows stronger bioactivity than the positive control obeticholic acid (OCA) against liver fibrosis.

HY-169792

HPG1860	FXR Aminotransferases (Transaminases)	Metabolic Disease Inflammation/Immunology
HPG1860 is an orally active, highly selective and potent FXR agonist, with an EC₅₀ of 18 nM (FXR-luciferase reporter assay). HPG1860 has EC₅₀ values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay). HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH) .

HY-W414824

3β,7β-Dihydroxy-5-cholestenoic acid	Endogenous Metabolite	Neurological Disease
3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid that displays elevated levels in Niemann-Pick type C and Niemann-Pick type B diseases, contributing to toxicity in oculomotor neurons. It is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) through the enzymatic action of hydroxysteroid 11-β dehydrogenase 1.

HY-B0607R

Nitisinone (Standard) NTBC (Standard); Nitisone (Standard); SC0735 (Standard)	HPPD Reference Standards	Metabolic Disease
Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .

HY-151959

FXR agonist 4	FXR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC₅₀ value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (1) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71792

	TYR Protein, Human (P.pastoris, His) 2 Publications Verification ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag.

HY-P79018

	TYR Protein, Human (HEK293, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	HEK293
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (HEK293, His) is the recombinant human-derived TYR protein, expressed by HEK293 , with N-6*His labeled tag.

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HY-P82582

	TRP1 Antibody (YA2327) CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP	WB, IHC-P, IP	Human
	DHICA Oxidase Antibody (YA2327) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2327), targeting DHICA Oxidase, with a predicted molecular weight of 61 kDa (observed band size: 61 kDa). DHICA Oxidase Antibody (YA2327) can be used for WB, IHC-P, IP experiment in human background.

HY-P86053

	Tyrosinase Antibody (YA5745) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, ICC/IF, ELISA	Human
	Tyrosinase Antibody (YA5745) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosinase. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P82467

	BOB1 Antibody (YA2212) BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2af1	WB, IHC-P, ICC/IF, FC	Human
	BOB1 Antibody (YA2212) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2212), targeting BOB1, with a predicted molecular weight of 27 kDa (observed band size: 35 kDa). BOB1 Antibody (YA2212) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

HY-P85966

	Tyrosinase Antibody (YA5658) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	Tyrosinase Antibody (YA5658) is a mouse-derived and non-conjugated IgA monoclonal antibody, targeting to Tyrosinase. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

HY-P81502

	TRP1 Antibody (YA1247) CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP; DHICA oxidase	IHC-P	Human
	TRP1 Antibody (YA1247) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1247), targeting TRP1. TRP1 Antibody (YA1247) can be used for IHC-P experiment in human background.

HY-P85829

	BOB.1 Antibody (YA5521) B cell Oct binding protein 1; B cell specific coactivator OBF 1; B cell specific coactivator OBF1; B-cell-specific coactivator OBF-1; BOB 1; BOB-1; OBF 1; OBF1; OBF1_HUMAN; OCA B; OCA-B; OCAB; OCT binding factor 1; OCT-binding factor 1; POU class 2 associating factor 1; POU domain class 2 associating factor 1; POU domain class 2-associating factor 1; Pou2af1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	BOB.1 Antibody (YA5521) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB.1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

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OCA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
OCA2 Human Pre-designed siRNA Set A contains three designed siRNAs for OCA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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