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Neurofilament Light Chain (NfL)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	iGluR (1) Toll-like Receptor (TLR) (2) TRP Channel (1)
By Research Areas:	Neurological Disease (3)

3

Inhibitors & Agonists

1

Antibodies

Targets Recommended: ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SARM1-IN-4	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).

FP802	TRP Channel iGluR	Neurological Disease
FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology .FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 can be used for AD and ALS research ^[1][2].

SARM1-IN-7	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-7 is a potent active site (orthosteric) and orally active SARM1 inhibitor. SARM1-IN-7 continuously activates the enzymatic activity of SARM1, thereby exacerbating the depletion of NAD at sub-minimal concentrations. SARM1-IN-7 demonstrated dual benefits in the SARM1-activated cell models and mouse models: a high dose exerted a cell/neuron protective effect, while a low dose exacerbated cell/neuron damage. SARM1-IN-7 can be used for the study of axon degeneration .

Cat. No.	Compare	Product Name	Application	Reactivity

	Neurofilament/NF-L Antibody (YA6394) Neurofilament L; Neurofilament 68; Neurofilament triplet L; 70 kD Neurofilament Light; 68kDa Neurofilament protein; CMT 1F; CMT 2E; CMT1F; CMT2E; FLJ53642; Light molecular weight Neurofilament protein; NEFL; Neurofilament Light; Neurofilament Light polypeptide 68kDa; Neurofilament Light polypeptide; Neurofilament protein, Light Chain; Neurofilament subunit NF L; Neurofilament triplet L protein; NF 68; NF L; NF68; NFL; NFL_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	Neurofilament/NF-L Antibody (YA6394) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neurofilament/NF-L.

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