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Necrocide1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14307
    Necrocide 1

    		TRP Channel Eukaryotic Initiation Factor (eIF) Reactive Oxygen Species (ROS) Cancer
    Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer [1] .
    Necrocide 1
  • HY-14307A
    (R)-Necrocide 1

    		Drug Isomer Cancer
    (R)-Necrocide 1 (compound (R)-38) a potent anticancer agent. (R)-Necrocide 1 has antiproliferative activity [1].
    (R)-Necrocide 1

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