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Nav1.2-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176065
    Nav1.2-IN-1

    		Sodium Channel Neurological Disease
    Nav1.2-IN-1 (compound 5i), a 3-(1,2,3,6-tetrahydropyridine)-4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC50 value of 7.79 μM. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ)-induced epilepsy mode. Nav1.2-IN-1 exhibits antiepileptic activity .
    Nav1.2-IN-1

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