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Na -Ca2 Exchanger

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/Ca2+ Exchanger (18) Na+/H+ Exchanger (NHE) (1) Sodium Channel (4) Angiotensin Receptor (3) Autophagy (1) Calcium Channel (4) Isotope-Labeled Compounds (1) P2X Receptor (1) Potassium Channel (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (13) Endocrinology (3) Metabolic Disease (3) Neurological Disease (11)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Na+/Ca2+ Exchanger Na+/H+ Exchanger (NHE) CRAC Channel Na+/HCO3- Cotransporter Na+/K+ ATPase Sodium Channel NKCC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128678

ORM-10103	Na+/Ca2+ Exchanger	Cardiovascular Disease
ORM-10103 is a specific inhibitor of the *Na+/Ca2+ exchanger* (NCX), which decreases the NCX current with estimated IC₅₀**s of 55 and 67 nM at -80 and at 20 mV, respectively .

HY-16952A

Bepridil hydrochloride hydrate 5+ Cited Publications (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate	Calcium Channel	Cardiovascular Disease
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca ⁺ channel antagonist and Na ⁺, K ⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac *Na ⁺/Ca2* ⁺ exchange (NCX1)** inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders .

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-100298

Caldaret MCC-135	Na+/Ca2+ Exchanger	Cardiovascular Disease
Caldaret is an intracellular *Ca ²⁺* handling modulator that acts through reverse mode Na ⁺/Ca ²⁺ *exchanger* inhibition.

HY-15754

CGP37157 5+ Cited Publications	Na+/Ca2+ Exchanger	Neurological Disease Cancer
CGP37157 is a potent, selective inhibitor of Na ⁺/Ca ²⁺ exchanger, inhibiting the Na ⁺-induced Ca ²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-P10811

*Na2+ - Ca2+ Exchanger* inhibitory peptide** XIP	Na+/Ca2+ Exchanger	Neurological Disease
Na ⁺-Ca ²⁺ Exchanger inhibitory peptide (XIP) is a Na ⁺-Ca ²⁺ exchanger inhibitor with a K_i of 200 nM. Na ⁺-Ca ²⁺ Exchanger inhibitory peptide inhibits the Na ⁺-dependent Ca ²⁺ uptake and the Na ⁺-dependent Ca ²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner .

HY-160508

NCX1-IN-1	Na+/H+ Exchanger (NHE)	Neurological Disease
NCX1-IN-1 (Compound 6) is the inhibitor for Na+/Ca2+ exchanger(NCX) .

HY-15515R

SEA0400 (Standard)	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

HY-B1546AR

Benzamil hydrochloride (Standard)	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (hydrochloride) (Standard) is the analytical standard of Benzamil (hydrochloride). This product is intended for research and analytical applications. Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM .

HY-A0236AR

Aprindine hydrochloride (Standard)	Potassium Channel	Cardiovascular Disease
Aprindine (hydrochloride) (Standard) is the analytical standard of Aprindine (hydrochloride). This product is intended for research and analytical applications. Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-15515

SEA0400 Maximum Cited Publications 18 Publications Verification	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-W710915

Aprindine hydrochloride-d10	Isotope-Labeled Compounds Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na ⁺/H ⁺ and *Na ⁺/Ca ²⁺* exchange transport**, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-100928

YS 035 hydrochloride	Calcium Channel	Neurological Disease
YS 035 hydrochloride is a *Ca ²⁺* antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca ²⁺ uptake by muscle cells and inhibits Na ⁺/Ca ²⁺ exchange (K_i=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca ²⁺ transport .

HY-164684

Dichlorobenzamil 3',4'-Dichlorobenzamil; L-594881	Calcium Channel Sodium Channel Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective *Na/Ca* exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse *Na/Ca* exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K ⁺ channels and voltage-sensitive *Ca ²⁺* channels .

HY-107658

SN 6 5+ Cited Publications	Na+/Ca2+ Exchanger	Cardiovascular Disease
SN 6 is a selective *Na ⁺/Ca ²⁺* exchanger (NCX)** inhibitor, and inhibits ⁴⁵Ca ²⁺ uptake by NCX1, NCX2, and NCX3, with IC₅₀s of 2.9, 16, and 8.6 μM, respectively.

HY-B1546

Benzamil Benzylamiloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a *Na ⁺/Ca ²⁺* exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC)** blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-B1546A

Benzamil hydrochloride 1 Publications Verification Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca ²⁺-activated currents, with an IC₅₀ of 1.1 μM .

HY-15415

KB-R7943 mesylate 4 Publications Verification	Na+/Ca2+ Exchanger Autophagy	Cancer
KB-R7943 mesylate is a widely used inhibitor of the reverse Na ⁺/Ca ²⁺ exchanger (NCX_rev) with IC₅₀ of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

HY-N15474

12-O-Deacetyl-phomoxanthone A	Na+/Ca2+ Exchanger	Cancer
12-O-Deacetyl-phomoxanthone A, a Na ⁺/Ca ²⁺ exchanger 1 (NCX1) activator, causes an increase in cellular Ca ²⁺ signaling and subsequent inhibition of the downstream PI3K/AKT/β-catenin pathway. 12-O-Deacetyl-phomoxanthone A induces apoptosis and induces G1 phase arrest. 12-O-Deacetyl-phomoxanthone A can be used in the research for melanoma .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-136182A

YM-244769	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice .

HY-136182

YM-244769 dihydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 dihydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-107659

YM-244769 hydrochloride	Na+/Ca2+ Exchanger	Cardiovascular Disease Neurological Disease
YM-244769 hydrochloride is a potent, selective and orally active Na ⁺/Ca ²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca ²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice .

HY-101044

PPADS tetrasodium 5+ Cited Publications	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

Cat. No.	Product Name	Target	Research Area

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P10811

*Na2+ - Ca2+ Exchanger* inhibitory peptide** XIP	Na+/Ca2+ Exchanger	Neurological Disease
Na ⁺-Ca ²⁺ Exchanger inhibitory peptide (XIP) is a Na ⁺-Ca ²⁺ exchanger inhibitor with a K_i of 200 nM. Na ⁺-Ca ²⁺ Exchanger inhibitory peptide inhibits the Na ⁺-dependent Ca ²⁺ uptake and the Na ⁺-dependent Ca ²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15474

12-O-Deacetyl-phomoxanthone A	Structural Classification Flavonoids Microorganisms Source classification Biflavones	Na+/Ca2+ Exchanger
12-O-Deacetyl-phomoxanthone A, a Na ⁺/Ca ²⁺ exchanger 1 (NCX1) activator, causes an increase in cellular Ca ²⁺ signaling and subsequent inhibition of the downstream PI3K/AKT/β-catenin pathway. 12-O-Deacetyl-phomoxanthone A induces apoptosis and induces G1 phase arrest. 12-O-Deacetyl-phomoxanthone A can be used in the research for melanoma .

Cat. No.	Product Name	Chemical Structure

HY-W710915

Aprindine hydrochloride-d10
Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

Aprindine hydrochloride-d10

Aprindine hydrochloride-d₁₀ is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82586

	NCX1 Antibody (YA2331) Na+/Ca2+ Exchanger; NCX1; SLC8A1	WB	Human, Mouse, Rat
	NCX1 Antibody (YA2331) is a non-conjugated IgG antibody, targeting NCX1, with a predicted molecular weight of 109 kDa (observed band size: 109 kDa). NCX1 Antibody (YA2331) can be used for WB experiment in human, mouse, rat background.

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