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Results for "

NVL

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156467
    Neladalkib

    NVL-655

    		 Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity .
    Neladalkib
  • HY-156467A
    Neladalkib TFA

    NVL-655 TFA

    		 Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    Neladalkib TFA is the TFA salt form of Neladalkib (HY-156467). Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity .
    Neladalkib TFA
  • HY-152292
    Zidesamtinib

    NVL-520; NUV-520

    		 ROS Kinase Cancer
    Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer .
    Zidesamtinib
  • HY-RS09707
    NVL Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NVL Human Pre-designed siRNA Set A contains three designed siRNAs for NVL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NVL Human Pre-designed siRNA Set A
    NVL Human Pre-designed siRNA Set A
  • HY-175783
    MM927

    		Apoptosis Cancer
    MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) .
    MM927

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