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Results for "

NTS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Histone Demethylase (2) Histone Methyltransferase (1) Liposome (1) Neurotensin Receptor (5) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Infection (2) Neurological Disease (8)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Phospholipids (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10275

*Tat-NTS* peptide**	Apoptosis	Neurological Disease
Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke .

HY-148650

Sortilin antagonist 1	Neurotensin Receptor	Neurological Disease
Sortilin antagonist 1 (compound 44) is a sortilin antagonist with an IC₅₀ value of 20 nM for inhibiting Neurotensin (NTS) binds to sortilin. Neurotensin is a sortilin ligand. Sortilin antagonist 1 can be used for the research of neurological disease .

HY-12436

NTRC-824	Neurotensin Receptor	Neurological Disease
NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC₅₀ of 38 nM and a K_i of 202 nM. NTRC-824 is >150-fold selectivity for *NTS2* over NTS1 (K_i >30 μM) .

HY-124831

NTRC-844	Neurotensin Receptor	Neurological Disease
NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC₅₀ of 238 nM. NTRC-844 plays an important role in analgesic animal research .

HY-P2544

[Lys8, Lys9]-Neurotensin (8-13) JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors *NTS1* and *NTS2, with K_i* values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .

HY-RS24084

Nts Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nts Rat Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nts Rat Pre-designed siRNA Set A Nts Rat Pre-designed siRNA Set A

HY-RS17624

Nts Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nts Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nts Mouse Pre-designed siRNA Set A Nts Mouse Pre-designed siRNA Set A

HY-RS09637

NTS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NTS Human Pre-designed siRNA Set A contains three designed siRNAs for NTS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NTS Human Pre-designed siRNA Set A NTS Human Pre-designed siRNA Set A

HY-P991147

Ledostomig	PD-1/PD-L1	Cancer
Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human netrin-5 (NTS5) and programmed death-1 (PD-1). Ledostomig is promising for research of various cancers .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-130463

POPG sodium salt PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)	Liposome	Neurological Disease
POPG sodium salt is a negatively charged phospholipid. POPG sodium salt affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG sodium salt increases the apparent affinity of Gαq and Gβ₁γ₁ for activated *NTS1*. POPG sodium salt can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research .

HY-P2025

JMV 236	Histone Methyltransferase	Neurological Disease
JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation .

HY-175185

MC3935	Histone Demethylase	Infection
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

Cat. No.	Product Name	Target	Research Area

HY-P10275

*Tat-NTS* peptide**	Apoptosis	Neurological Disease
Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke .

HY-P2544

[Lys8, Lys9]-Neurotensin (8-13) JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors *NTS1* and *NTS2, with K_i* values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-P2025

JMV 236	Histone Methyltransferase	Neurological Disease
JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation .

Cat. No.	Product Name	Target	Research Area

HY-P991147

Ledostomig	PD-1/PD-L1	Cancer
Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human netrin-5 (NTS5) and programmed death-1 (PD-1). Ledostomig is promising for research of various cancers .

Species:	Human (1) Mouse (1)
Tag:	Fc (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73743

	NTS/Neurotensin Protein, Human (HEK293, Fc) Neurotensin; neuromedin N; NmN-125; NmN; NTS	Human	HEK293
	Neurotensin, a neuropeptide, potentially modulates fat metabolism through endocrine or paracrine mechanisms, inducing smooth muscle contraction. It interacts with specific receptors like NTSR1 and binds to proteins, including SORT1 and SORL1, indicating involvement in diverse cellular processes and potential regulatory functions in fat metabolism. NTS/Neurotensin Protein, Human (HEK293, Fc) is the recombinant human-derived Neurotensin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77817

	NTS Protein, Mouse (HEK293, Fc) neuromedin N; neurotensin/neuromedin N	Mouse	HEK293
	NTS1/NTSR1, the neurotensin receptor 1, potentially regulates fat metabolism through endocrine or paracrine mechanisms. Interacting with its ligand, neurotensin, NTS1/NTSR1 induces smooth muscle contraction. The receptor's interactions with neurotensin and other proteins like SORT1 and SORL1 suggest involvement in diverse cellular processes, indicating potential implications for fat metabolism regulation. NTS Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived NTS protein, expressed by HEK293, with C-hFc labeled tag.

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