NS 1

By Targets:	Antibiotic (2) Bacterial (3) Endogenous Metabolite (3) Fungal (1) Influenza Virus (2) Parasite (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4) Infection (7)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS07001

IVNS1ABP Human Pre-designed siRNA Set A ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068	Small Interfering RNA (siRNA)	Others
IVNS1ABP Human Pre-designed siRNA Set A contains three designed siRNAs for IVNS1ABP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IVNS1ABP Human Pre-designed siRNA Set A IVNS1ABP Human Pre-designed siRNA Set A

HY-RS11416

PTPN11 Human Pre-designed siRNA Set A CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3	Small Interfering RNA (siRNA)	Others
PTPN11 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTPN11 Human Pre-designed siRNA Set A PTPN11 Human Pre-designed siRNA Set A

HY-134922

NS1-IN-1	Influenza Virus	Infection
NS1-IN-1 (compound 3) is a potent *NS1* inhibitor. NS1 is a major influenza A virus virulence factor that inhibits host gene expression. NS1-IN-1 decreases viral protein levels, contributing to the reduction of virus replication. NS1-IN-1 shows antiviral activity by repressing the activity of mTORC1 in a TSC1-TSC2-dependent manner .

HY-N11989

Nanangenine B	Others	Cancer
Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL .

HY-158925

Conglobatin C1	Endogenous Metabolite	Cancer
Conglobatin C1 is a bacterial metabolite and has anticancer activity. Conglobatin C1 is cytotoxic to NS-1 mouse myeloma cells (IC₅₀ = 1.05 μg/mL) .

HY-118427

Asterriquinol D dimethyl ether	Parasite Endogenous Metabolite	Infection Cancer
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC₅₀ of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits *Tritrichomonas foetus* .

HY-125092

Drimentine C	Antibiotic	Infection
Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/mL, respectively.

HY-118079

Drimentine B	Endogenous Metabolite	Infection
Drimentine B is a terpenylated diketopiperazine originally isolated from Actinomycete bacteria that has anticancer activity. It inhibits the proliferation of NS-1 murine β lymphocyte myeloma cells by 41 and 59% in vitro when used at concentrations of 50 and 100 μg/mL, respectively.

HY-N10259

Norfunalenone	Bacterial	Infection Cancer
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC₅₀ of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC₅₀=265 μM) .

HY-N12264

Burnettramic acid A	Antibiotic Bacterial Fungal	Infection
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC₅₀ of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC₅₀ of 13.8 μg/mL .

HY-126136

ML303	Influenza Virus	Infection
ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC₉₀ = 155 nM), with an EC₅₀ of 0.7 μM for Influenza A virus H1N1 .

HY-156004

Ziapin 2	Bacterial	Others
Ziapin 2 is a molecular optomechanical light transducer. Ziapin 2 is an amphiphilic azobenzene with a strong non-covalent affinity to the plasma membrane. Ziapin 2 can be used to photo-modulate the membrane potential in cells of the Gram-positive bacterium Bacillus subtilis. Ziapin 2 enters the lipid membrane very rapidly (≈ 40 ns) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11989

Nanangenine B	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL .

HY-158925

Conglobatin C1	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Endogenous Metabolite
Conglobatin C1 is a bacterial metabolite and has anticancer activity. Conglobatin C1 is cytotoxic to NS-1 mouse myeloma cells (IC₅₀ = 1.05 μg/mL) .

HY-118427

Asterriquinol D dimethyl ether	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Parasite Endogenous Metabolite
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC₅₀ of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits *Tritrichomonas foetus* .

HY-N10259

Norfunalenone	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Bacterial
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC₅₀ of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC₅₀=265 μM) .

HY-N12264

Burnettramic acid A	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Bacterial Fungal
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC₅₀ of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC₅₀ of 13.8 μg/mL .

Recombinant Proteins Recommended:

DENV Non-structural Protein 1 (NS1)

Species:	Virus (8) Human (3)
Tag:	His (10) Tag Free (1) Strep (1)
Source:	HEK293 (6) Sf9 insect cells (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73740

	NS1 Protein, Dengue virus 2 (HEK293, His) DEN-2; Dengue NS1 protein; Dengue virus Type 2; DENV2; DENV2-NS1	Virus	HEK293
	NS5 Protein is part of the flavivirus RNA replication complex (RC) composed of viral non-structural proteins and host-cell cofactors. NS5 is the largest flavivirus protein, the most conserved, which act as two domains, the RNA-dependent RNA polymerase (RdRp) and RNA methyltransferase enzyme (MTase). NS5 plays a fundamental role in flavivirus replication, viral RNA methylation, RNA polymerization, and host immune system evasion. NS1 Protein, Dengue virus 2 (HEK293, His) is the recombinant Virus-derived NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P75290

	NS1 Protein, Dengue virus 1 (HEK293, His) DENV-NS1 Protein; DENV; Dengue virus (DENV) (type 1, strain US/Hawaii/1944) DENV-NS1 Protein	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.NS1 Protein, Dengue virus 1 (HEK293, His) is the recombinant Virus-derived NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74455

	*Zika virus NS1* Protein (HEK293, His)** Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS1 protein	Virus	HEK293
	Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication.Zika virus NS1 Protein (HEK293, His) is the recombinant Virus-derived Zika virus NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74684

	*Non-structural protein 1/NS1* Protein, H1N1 (His)** Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural / NS1 Protein (His)	Virus	E. coli
	Nonstructural protein 1/NS1 plays multiple roles in viral infection.It inhibits cellular pre-mRNA processing by binding to CPSF4 and PABPN1, disrupting normal 3' end processing and halting host protein synthesis.Non-structural protein 1/NS1 Protein, H1N1 (His) is the recombinant Virus-derived Non-structural protein 1/NS1 protein, expressed by E.coli , with N-His labeled tag.

HY-P700618

	SHP-2 Protein, Human (T253M, Q257L, His) protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;	Human	E. coli
	The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L mutation.

HY-P73738

	NS1 Protein, Dengue virus 4 (HEK293, His) DEN-4; Dengue Virus 4 NS1; Dengue virus Type 4; DENV4; DENV4-NS1	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. NS1 Protein, Dengue virus 4 (HEK293, His) is the recombinant Virus-derived NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P73739

	NS1 Protein, Dengue virus 3 (HEK293, His) DEN-3; Dengue Virus 3 NS1; Dengue virus Type 3; DENV3; DENV3-NS1	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. NS1 Protein, Dengue virus 3 (HEK293, His) is the recombinant Virus-derived NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74464

	*West Nile Virus NS1* Protein (HEK293, His)** West Nile Virus (WNV) (lineage 1, strain NY99) NS1 Protein	Virus	HEK293
	West Nile Virus NS1 Protein is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms. WNV NS1 has an unusual structure-function because it is glycosylated and forms different structures to facilitate different roles intracellularly and extracellularly, including roles in the replication complex, assisting in virus assembly, and complement antagonism. It also plays a role in protective immunity through antibody-mediated cellular cytotoxicity, and anti-NS1 antibodies elicit passive protection in animal models against a virus challenge. West Nile Virus NS1 Protein (HEK293, His) is the recombinant Virus-derived West Nile Virus NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74454

	*Zika virus NS1* Protein (sf9, His)** Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS1 protein	Virus	Sf9 insect cells
	Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication.Zika virus NS1 Protein (sf9, His) is the recombinant Virus-derived Zika virus NS1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P701572

	IVNS1ABP Protein, Human (sf9) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; Kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (sf9) is the recombinant human-derived IVNS1ABP protein, expressed by sf9 insect cells , with tag free.

HY-P701573

	IVNS1ABP Protein, Human (sf9, His, StrepⅡ) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; Kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (sf9, His, Strep) is the recombinant human-derived IVNS1ABP protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

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HY-P82093

	hnRNP Q Antibody (YA1838) SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	hnRNP Q Antibody (YA1838) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1838), targeting hnRNP Q, with a predicted molecular weight of 70 kDa (observed band size: 65-82 kDa). hnRNP Q Antibody (YA1838) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P84492

	PTPN11 Antibody (YA4189) CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3; MGC14433	IHC-P, ICC/IF, FC, ELISA	Human

HY-P84919

	*CPV-NS1* Antibody (YA4616)** Canine parvovirus noNStructural protein 1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS07001

IVNS1ABP Human Pre-designed siRNA Set A ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068		siRNAs Human Pre-designed siRNA Sets
IVNS1ABP Human Pre-designed siRNA Set A contains three designed siRNAs for IVNS1ABP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11416

PTPN11 Human Pre-designed siRNA Set A CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3		siRNAs Human Pre-designed siRNA Sets
PTPN11 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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