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NLRP3-IN-81

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174312
    NLRP3-IN-81

    		NOD-like Receptor (NLR) Pyroptosis Caspase Interleukin Related Inflammation/Immunology
    NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes .
    NLRP3-IN-81

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