Search Result

Results for "

NG 108-15

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) Calcium Channel (1) Cyclic GMP-AMP Synthase (1) MMP (1) Nucleoside Antimetabolite/Analog (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Neurological Disease (2)
Oligonucleotides:	Nucleotide Analogs (1) Human Pre-designed siRNA Sets (1) Adenine Nucleotide (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: 15-PGDH Enteropeptidase EHD Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-W587488

Adenosine 3′-monophosphate 3′-AMP	Nucleoside Antimetabolite/Analog Cyclic GMP-AMP Synthase	Cancer
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors .

HY-10815

σ1 Receptor antagonist-1 1 Publications Verification	Sigma Receptor Apoptosis	Neurological Disease Cancer
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pK_i=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells .

HY-NP108

Highly purified type II collagen, from rat sternal cartilage Rat Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-RS10815

POGZ Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POGZ Human Pre-designed siRNA Set A contains three designed siRNAs for POGZ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POGZ Human Pre-designed siRNA Set A POGZ Human Pre-designed siRNA Set A

HY-P10815

IP3RCYT	Apoptosis Calcium Channel	Others
IP3RCYT is an IP₃R inhibitory peptide, which can inhibit the binding of cytochrome C to IP₃R with an IC₅₀ about 100 nM. IP3RCYT regulates calcium signaling within cells. P3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with Staurosporine (HY-15141) or Membrane-bound Fas ligand (FasL) .

HY-N10815

Anthriscinol	Others	Others
Anthriscinol is a natural product that can be isolated from Anthriscus sylvestris HOFFM .

Cat. No.	Product Name

HY-L108

Antidepressant Compound Library	2,402 compounds
Depression is a serious global affective disorder and one of the most common neurological diseases whose clinical manifestations are low mood, loss of interest, anhedonia, loss of energy, and fatigue, people with major depressive disorder (MDD) can even have suicidal thoughts and behaviors. Currently available antidepressants have significant limitations, including a long time lag for a therapeutic response (weeks to months) and low response rates. This is particularly problematic for a disease with a high suicide rate. Therefore, the development of new antidepressant drugs is particularly urgent. MCE offers a unique collection of 2,402 compounds with antidepressant activities or targeting the unique targets of depression. MCE Antidepressant Compound Library is a useful tool for exploring the mechanism of depression and discovering new drugs for depression.

Antidepressant Compound Library

2,402 compounds

Depression is a serious global affective disorder and one of the most common neurological diseases whose clinical manifestations are low mood, loss of interest, anhedonia, loss of energy, and fatigue, people with major depressive disorder (MDD) can even have suicidal thoughts and behaviors.

Currently available antidepressants have significant limitations, including a long time lag for a therapeutic response (weeks to months) and low response rates. This is particularly problematic for a disease with a high suicide rate. Therefore, the development of new antidepressant drugs is particularly urgent.

MCE offers a unique collection of 2,402 compounds with antidepressant activities or targeting the unique targets of depression. MCE Antidepressant Compound Library is a useful tool for exploring the mechanism of depression and discovering new drugs for depression.

Cat. No.	Product Name	Type