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Mitotic kinesin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kinesin (17) Apoptosis (2) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) Microtubule/Tubulin (1) Mitosis (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (5)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Antibodies

Targets Recommended: Kinesin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145034

KIF18A-IN-1 1 Publications Verification	Kinesin	Cancer
KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells .

HY-50672

MK-0731	Kinesin Apoptosis Lipoxygenase	Cancer
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 2.2 nM and a pK_a of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .

HY-15000

EMD534085	Kinesin	Cancer
EMD534085 is a potent and selective inhibitor of the mitotic *kinesin-5* with an IC₅₀ of 8 nM.

HY-12069

SB-743921 hydrochloride 5 Publications Verification	Kinesin	Cancer
SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a K_i of 0.1 nM.

HY-101071A

Monastrol Maximum Cited Publications 8 Publications Verification (±)-Monastrol	Kinesin Apoptosis	Cancer
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC₅₀ value of 14 μM.

HY-177246A

Mitotic kinesin-IN-1 hydrochloride	Kinesin	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Mitotic kinesin-IN-1 (Example 80) hydrochloride is a **Mitotic kinesin** inhibitor. Mitotic kinesin-IN-1 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-1 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .

HY-177247A

Mitotic kinesin-IN-2 hydrochloride	Kinesin	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Mitotic kinesin-IN-2 (Page 135, fifteenth) hydrochloride is a **Mitotic kinesin** inhibitor. Mitotic kinesin-IN-2 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-2 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .

HY-177248A

Mitotic kinesin-IN-3 hydrochloride	Kinesin	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is a **Mitotic kinesin** inhibitor. Mitotic kinesin-IN-3 hydrochloride inhibits cell proliferation by suppressing mitosis. Mitotic kinesin-IN-3 hydrochloride can be used for cancer, cardiac hypertrophy, immune and inflammatory disorders, fungal infections research .

HY-119407

Terpendole E	Kinesin	Cancer
Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

HY-161112

LG157	Kinesin	Others
LG157 is a potent inhibitor of mitotic *kinesin*-like protein 2 (MKLP2) .

HY-15949

Kif15-IN-2	Kinesin	Cardiovascular Disease Inflammation/Immunology Cancer
Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.

HY-124823

Monastroline HR22C16	Kinesin	Others
Monastroline (HR22C16) is an effective and selective inhibitor of the mitotic kinesin Eg5, exhibiting strong cell permeability.

HY-15948

Kif15-IN-1 3 Publications Verification	Kinesin	Cardiovascular Disease Inflammation/Immunology Cancer
Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.

HY-14661

SB-743921 free base	Kinesin	Cancer
SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a K_i of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases .

HY-13224A

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-101071

(S)-Monastrol (+)-Monastrol	Kinesin Mitosis	Cancer
(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles .

HY-122247

PVZB1194	Kinesin	Cancer
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC₅₀ of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC₅₀: 5.5 μM). PVZB1194 can be used in the study of tumors .

HY-145827

KIF18A-IN-4	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119407

Terpendole E	Structural Classification Microorganisms Iridoids Terpenoids Source classification	Kinesin
Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

Cat. No.	Product Name	Chemical Structure

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82669

	MCAK Antibody (YA2414) KIF2C; KNSL6; kinesin-like protein KIF2C; kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK	WB, ICC/IF, FC	Human
	MCAK Antibody (YA2414) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCAK.

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Mitotic kinesin

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
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