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Me-(S,R,S)-AHPC-CO-CH2-Br

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131387
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736) .
    (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
  • HY-131168
    (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

    VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology .
    (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
  • HY-131864
    SJF-1528

    		EGFR PROTACs Cancer
    SJF-1528 is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 also degrades HER2 (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .
    SJF-1528
  • HY-131864A
    SJF-1528 hemihydrate

    		PROTACs EGFR Cancer
    SJF-1528 hemihydrate is the hemihydrate form of SJF-1528 (HY-131864). SJF-1528 hemihydrate is a EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
    SJF-1528 hemihydrate
  • HY-163220
    (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc
  • HY-163231
    (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH
  • HY-173093
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH is the conjugate composed of an E3 ligase ligand and a linker. Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH can be used for synthesis of PROTAC degrader MS4322 (HY-141877) .
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH
  • HY-169970
    Me-(S,R,S)-AHPC-CO-CH2-Br

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Me-(S,R,S)-AHPC-CO-CH2-Br is an E3 ligase ligand-linker conjugate. Me-(S,R,S)-AHPC-CO-CH2-Br can be used to synthesize JNJ-1013 (HY-153188) .
    Me-(S,R,S)-AHPC-CO-CH2-Br
  • HY-163223
    (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc
  • HY-168026
    CEP1347-VHL-02

    		PROTACs Mixed Lineage Kinase Cancer
    CEP1347-VHL-02 is a PROTAC targeting MLK3. CEP1347-VHL-02 consists of PROTAC target protein ligand CEP-1347 (HY-10412) (red part), E3 ubiquitin ligase ligand (S,R,S)-AHPC-Me (HY-112078) (blue part) and PROTAC Linker Amino-PEG3-CH2COOH (HY-140189) (black part), of which the target protein ligand activity control is CEP-1347-acid (HY-168027), and the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 (HY-131387) [1] .
    CEP1347-VHL-02

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