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MS 4322

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141877
    MS4322
    1 Publications Verification

    YS43-22

    		 PROTACs Histone Methyltransferase Cancer
    MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )) .
    MS4322
  • HY-141877B
    MS4322 (isomer)

    YS43-22 (isomer)

    		 PROTACs Histone Methyltransferase Cancer
    MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )) .
    MS4322 (isomer)
  • HY-173092
    PRMT5 ligand 1

    		Histone Methyltransferase Ligands for Target Protein for PROTAC Cancer
    PRMT5 ligand 1 (compound 3) is the ligand for PRMT5 that can be used as target protein ligand for synthesis of PROTAC degrader MS4322 (HY-141877) .
    PRMT5 ligand 1
  • HY-173093
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH is the conjugate composed of an E3 ligase ligand and a linker. Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH can be used for synthesis of PROTAC degrader MS4322 (HY-141877) .
    Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH

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