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MRL-SYKi

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178129
    MRL-SYKi

    		Syk Inflammation/Immunology
    MRL-SYKi is a chemical probe with high selectivity and potent activity against spleen tyrosine kinase (SYK). MRL-SYKi potently binds to SYK gain-of-function (GoF) variants (SYK(S550Y), SYK(S550F), and SYK(P342T)) in intact live cells, with IC50 values of 2.1 nM, 14 nM, and 4.6 nM respectively in digitonin-permeabilized cell assays. MRL-SYKi effectively reduces catalytic activity (IC50 = 63 nM for SYK(S550F) and 95 nM for SYK(P342T) in PhosphoSens SOX peptide assays). MRL-SYKi can decrease the phosphorylation level of SYK(S550Y) at Y525/526 in SW480 cells. MRL-SYKi can be used for the study of inflammation .
    MRL-SYKi

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