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MGL-IN-1

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

1

Peptides

8

Natural
Products

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119033
    MGL-IN-1

    		MAGL Inflammation/Immunology
    MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant [1].
    MGL-IN-1
  • HY-167887
    7PPD-Q

    		Endogenous Metabolite Infection
    7PPD-Q is a substituted p-phenylenediamine antioxidants derivatives. 7PPD-Q has toxic to the bacterium V. fischeri (EC50 = 14.9 mg/L) .
    7PPD-Q
  • HY-122298
    Fenpicoxamid

    XDE 777

    		 Antibiotic Fungal Infection
    Fenpicoxamid is a new fungicide. Fenpicoxamid inhibits the growth of the fungus Z. tritici with an EC50 value of 0.051 mg/L .
    Fenpicoxamid
  • HY-W268942
    4-Nitrosodiphenylamine

    		Bacterial Infection Inflammation/Immunology
    4-Nitrosodiphenylamine shows great antibacterial activity against Erwinia amylovora, with an EC50 value of 5.715 mg/L .
    4-Nitrosodiphenylamine
  • HY-149400
    GABA-IN-2

    		GABA Receptor Infection
    GABA-IN-2 (Compound 5) is a GABA inhibitor. GABA-IN-2 has larvicidal activity and insecticidal effect, with mortality rates of 87% at 50 mg/L .
    GABA-IN-2
  • HY-149399
    GABA-IN-1

    		GABA Receptor Infection
    GABA-IN-1 (Compound 6) is a GABA inhibitor. GABA-IN-1 has larvicidal activity and insecticidal effect, with mortality rates of 93% at 50 mg/L .
    GABA-IN-1
  • HY-169571
    Antimicrobial agent-38

    		Bacterial Infection
    Antimicrobial agent-38 (compound 10) is a potent inhibitor of methicillin-resistant S. aureus strain ATCC 700699 and nonresistant strain ATCC 29213, with MICs of 32 and 64 mg/L .
    Antimicrobial agent-38
  • HY-155334
    RyRs activator 4

    		Parasite Others
    RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC50 value of 1.32 mg/L .
    RyRs activator 4
  • HY-168527
    Acaricide agent 1

    		Histone Demethylase Cancer
    Acaricide agent 1 (Compound 7l) is a potent LSD1 inhibitor. LSD1 exhibits excellent acaricidal activity against egg of T. cinnabarinus with a LC50 of 0.0035 mg/L .
    Acaricide agent 1
  • HY-155700
    SDH-IN-6

    		Fungal Infection
    SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC50 value of 1.77 mg/L .
    SDH-IN-6
  • HY-N9075
    9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one

    		Glycosidase Cancer
    9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC50: 3.86 mg/L) .
    9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one
  • HY-N3706
    Dehydro-α-lapachone

    		Fungal Infection
    Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L .
    Dehydro-α-lapachone
  • HY-19806
    Ceftolozane

    CXA-101 free base; FR264205 free base

    		 Antibiotic Bacterial Infection
    Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L .
    Ceftolozane
  • HY-124879
    MF 961

    		Bacterial Infection
    MF 961 is a quinolone biocide. The MIC50 values ​of MF 961 against E. coli, Klebsiella sp., Enterobacter sp., Citrobacter sp., Citrobacter sp., and Shlgella sp. are all in the range of 0-25 mg/L .
    MF 961
  • HY-P5663
    Bombinin H-BO1

    		Bacterial Infection
    Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candida albicans, and the MIC value is 256 mg/L .
    Bombinin H-BO1
  • HY-172362
    SDH-IN-22

    		Succinate Dehydrogenase Fungal Infection
    SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC50 of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC50 of 0.5 mg/L .
    SDH-IN-22
  • HY-N1673
    2,5-Dihydroxybenzaldehyde

    Gentisaldehyde

    		 Bacterial Infection
    2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus strains with a MIC50 of 500 mg/L .
    2,5-Dihydroxybenzaldehyde
  • HY-N15374
    Hypercalin B

    		Bacterial Infection
    Hypercalin B is an antibacterial agent that can be isolated from the hexane and chloroform extracts of the plant Hypericum acmosepalum. Hypercalin B exhibits inhibitory activity against multidrug-resistant strains of Staphylococcus aureus, with a MIC range of 0.5-128 mg/L .
    Hypercalin B
  • HY-146109
    RyRs activator 1

    		Parasite Infection
    RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .
    RyRs activator 1
  • HY-163560
    Insecticidal agent 10

    		Parasite Others
    Insecticidal agent 10 (Compound 8c) is an inhibitor for chitinase, which inhibits OfChi-h and OfChtI with IC50 of 1.51 and 9.21 nM, respectively. Insecticidal agent 10 inhibits growth of Ostrinia furnacalis with LC50 of 22.14 mg/L .
    Insecticidal agent 10
  • HY-128780
    Upleganan

    SPR206

    		 Bacterial Infection Cancer
    Upleganan (SPR206), a polymyxin analogue, and shows antibiotic activity against multidrug resistant Gram-negative pathogen. The MIC values of Upleganan against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L .
    Upleganan
  • HY-158112
    Herbicidal agent 3

    		Herbicide Others
    Herbicidal agent 3 (compound 7A) shows herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus at a dosage of 90 g ai/ha. Herbicidal agent 3 inhibites Setaria viridis TKL (SvTKL) enzyme activity, with the IC50 of 0.740 mg/L .
    Herbicidal agent 3
  • HY-157015
    Antifungal agent 81

    		Fungal Infection
    Antifungal agent 81(G22)exhibitsexcellent in vitro antifungal activities against Valsa mali withIC50values of 0.48 mg/L. Antifungal agent 81also exhibits excellent in vivo protective againstV. maliat 40 mg/L .
    Antifungal agent 81
  • HY-159486
    SDH-IN-18

    		Succinate Dehydrogenase Fungal Infection
    SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 of 0.48 and 1.4 mg/L .
    SDH-IN-18
  • HY-167892
    DRF-8417

    		Antibiotic Bacterial Infection Inflammation/Immunology
    DRF-8417, an oxazolidinone antibiotic, is active against Gram-positive and fastidious Gram-negative bacteria. DRF 8417 exhibits potent activity against Gram-positive pathogens with MIC50 and MIC90 values ranging from 0.06 to 1 mg/L .
    DRF-8417
  • HY-139983
    SDH-IN-1
    1 Publications Verification

    		 Fungal Infection
    SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L) .
    SDH-IN-1
  • HY-N10269
    Phomalactone

    		Fungal Endogenous Metabolite Infection
    Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .
    Phomalactone
  • HY-163890
    Succinate dehydrogenase-IN-2

    		Succinate Dehydrogenase Parasite Infection
    Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC50 of 0.52-3.42 mg/L .
    Succinate dehydrogenase-IN-2
  • HY-14780
    Viquidacin

    NXL 101

    		 Antibiotic Topoisomerase DNA/RNA Synthesis Bacterial Infection
    Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L .
    Viquidacin
  • HY-N10069
    Bonducellin

    		Bacterial Infection
    Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .
    Bonducellin
  • HY-118906
    BO-1165

    		Antibiotic Bacterial Infection
    BO-1165 is an antibiotic with good antibacterial activity against Gram-negative bacteria, but almost no activity against Gram-positive bacteria and anaerobic bacteria. BO-1165 has high antibacterial activity against Pseudomonas aeruginosa (MIC50=3.12 mg/L) and P. cepacia (MIC50=1.56 mg/L) .
    BO-1165
  • HY-128780B
    SPR206 acetate
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L .
    SPR206 acetate
  • HY-W272217
    Octacosane

    n-Octacosane; NSC 5549

    		 Endogenous Metabolite Bacterial Inflammation/Immunology Cancer
    Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .
    Octacosane
  • HY-170378
    Laccase-IN-5

    		Fungal Infection
    Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L .
    Laccase-IN-5
  • HY-172810
    Succinate dehydrogenase-IN-8

    		Succinate Dehydrogenase Fungal Infection
    Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L) .
    Succinate dehydrogenase-IN-8
  • HY-161010
    DHFR-IN-13

    		Dihydrofolate reductase (DHFR) Infection
    DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC50 value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC50 value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC50 value of 38.2 mg/L .
    DHFR-IN-13
  • HY-W272217R
    Octacosane (Standard)

    n-Octacosane (Standard); NSC 5549 (Standard)

    		 Reference Standards Endogenous Metabolite Bacterial Inflammation/Immunology Cancer
    Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .
    Octacosane (Standard)
  • HY-156339
    GABA receptor Antagonist 1

    		GABA Receptor Others
    GABA receptor Antagonist 1 (compound 7w) inhibits Px RDL1 GABAR with an IC50 value of 7.08 nmol/L. GABA receptor Antagonist 1 shows insecticide activity against P. xylostella, S. frugiperda, S. exigua, and S. litura, with LC50 of 0.09, 0.84, 0.87, and 0.68 mg/L respectively. GABA receptor Antagonist 1 shows a medium toxicity to honeybee (48 h, ID50 = 2.22 μg/adult), and low toxicity to zebrafish (LC50: 42.4 mg/L) .
    GABA receptor Antagonist 1

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