M-CAM

By Targets:	Apoptosis (2) MMP (1) Opioid Receptor (1) PACAP Receptor (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Calmodulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P11288A

ANT308 TFA	PACAP Receptor Apoptosis	Cancer
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of *MCAM* and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-135698

Methocinnamox M-CAM	Opioid Receptor	Neurological Disease
Methocinnamox (M-CAM) a selective and long-acting μ-opioid receptor (MOR) antagonist with a K_i of 0.6 nM. Methocinnamox binds to the orthosteric site of the MOR in a pseudo-irreversible, non-covalent manner, resulting in prolonged receptor blockade that persists until new receptors are synthesized. Methocinnamox acts as a reversible antagonist at both the kappa-opioid receptor (KOR) (K_i = 4.9 nM) and delta-opioid receptor (DOR) (K_i = 2.2 nM), and it exhibits no intrinsic agonist activity at these receptors. Methocinnamox can be used to reverse and prevent opioid overdose and addiction .

HY-RS08215

MCAM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MCAM Human Pre-designed siRNA Set A contains three designed siRNAs for MCAM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCAM Human Pre-designed siRNA Set A MCAM Human Pre-designed siRNA Set A

HY-RS24435

Mcam Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mcam Rat Pre-designed siRNA Set A contains three designed siRNAs for Mcam gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mcam Rat Pre-designed siRNA Set A Mcam Rat Pre-designed siRNA Set A

HY-RS17964

Mcam Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mcam Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mcam gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mcam Mouse Pre-designed siRNA Set A Mcam Mouse Pre-designed siRNA Set A

HY-P11288

ANT308	PACAP Receptor Apoptosis	Cancer
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of *MCAM* and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P991609

ABX-MA1	MMP	Cancer
ABX-MA1 is a humanized IgG2 monoclonal antibody inhibitor targeting *MCAM/MUC18. ABX-MA1 significantly decreases homotypic aggregation and heterotypic adhesion to HUVECs, and the formation of experimental lung metastasis. ABX-MA1 potently inhibits tumor growth, angiogenesis, and MMP-2* expression in A375SM/WM2664 xenograft mice model, promising for melanoma research .

Cat. No.	Product Name	Target	Research Area

HY-P11288A

ANT308 TFA	PACAP Receptor Apoptosis	Cancer
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of *MCAM* and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

HY-P11288

ANT308	PACAP Receptor Apoptosis	Cancer
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of *MCAM* and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM) .

Cat. No.	Product Name	Target	Research Area

HY-P99658

Imaprelimab PRX-003	Inhibitory Antibodies	Cancer
Imaprelimab (PRX-003) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody. Imaprelimab is an antineoplastic agent .

HY-P991609

ABX-MA1	MMP	Cancer
ABX-MA1 is a humanized IgG2 monoclonal antibody inhibitor targeting *MCAM/MUC18. ABX-MA1 significantly decreases homotypic aggregation and heterotypic adhesion to HUVECs, and the formation of experimental lung metastasis. ABX-MA1 potently inhibits tumor growth, angiogenesis, and MMP-2* expression in A375SM/WM2664 xenograft mice model, promising for melanoma research .

Species:	Human (3) Mouse (1) Cynomolgus (1)
Tag:	His (4) Fc (1)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P75611

	*CD146/MCAM* Protein, Human (HEK293, Fc)** Cell surface glycoprotein MUC18; CD146; MCAM; MUC18	Human	HEK293
	The CD146/MCAM protein is critical for maintaining endothelial monolayer integrity and cell adhesion in vascular tissue. Its expression promotes the interaction of melanoma cells with the vasculature and may contribute to tumor spread through the bloodstream. CD146/MCAM Protein, Human (HEK293, Fc) is the recombinant human-derived CD146/MCAM protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75612

	*CD146/MCAM* Protein, Human (HEK293, His)** Cell surface glycoprotein MUC18; CD146; MCAM; MUC18	Human	HEK293
	The CD146/MCAM protein is critical for maintaining endothelial monolayer integrity and cell adhesion in vascular tissue. Its expression promotes the interaction of melanoma cells with the vasculature and may contribute to tumor spread through the bloodstream. CD146/MCAM Protein, Human (HEK293, His) is the recombinant human-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag.

HY-P76201

	*CD146/MCAM* Protein, Mouse (HEK293, His)** Cell surface glycoprotein MUC18; Gicerin; CD146; Muc18	Mouse	HEK293
	The CD146/MCAM protein is a multifunctional adhesion regulator that plays a crucial role in maintaining endothelial monolayer adhesion in vascular tissue. Its expression is associated with promoting interactions between melanoma cells and vascular components, potentially enhancing hematogenous spread of tumors. CD146/MCAM Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag.

HY-P75613

	*CD146/MCAM* Protein, Human (Biotinylated, HEK293, His)** Cell surface glycoprotein MUC18; CD146; MCAM; MUC18	Human	HEK293
	The CD146/MCAM protein is critical for maintaining endothelial monolayer integrity and cell adhesion in vascular tissue. Its expression promotes the interaction of melanoma cells with the vasculature and may contribute to tumor spread through the bloodstream. CD146/MCAM Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag.

HY-P78582

	*CD146/MCAM* Protein, Cynomolgus (HEK293, His)** MCAM; CD146; MUC18	Cynomolgus	HEK293
	The CD146/MCAM protein is a multifunctional adhesion regulator that plays a crucial role in maintaining endothelial monolayer adhesion in vascular tissue. Its expression is associated with promoting interactions between melanoma cells and vascular components, potentially enhancing hematogenous spread of tumors. CD146/MCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of CD146/MCAM Protein, Cynomolgus (HEK293, His) is 536 a.a., with molecular weight of 80-110 kDa.

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HY-P80595

	CD146 Antibody (YA544) A32 antigen antibody; CD 146 antibody; CD146 antibody; CD146 antigen antibody; Cell surface glycoprotein MUC18 antibody; Cell surface glycoprotein P1H12 antibody; Gicerin antibody; MCAM antibody; Melanoma adhesion molecule antibody; Melanoma associated antigen A32 antibody; Melanoma associated antigen MUC18 antibody; Melanoma associated glycoprotein MUC18 antibody; Melanoma cell adhesion molecule antibody; Melanoma-associated antigen A32 antibody; Melanoma-associated antigen MUC18 antibody; MelCAM antibody; MUC 18 antibody; MUC18 antibody; MUC18_HUMAN antibody; S endo 1 antibody; S endo 1 endothelial associated antigen antibody; S-endo 1 endothelial-associated antigen antibody;	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	CD146 Antibody (YA544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD146.

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Cat. No.	Product Name		Classification

HY-RS08215

MCAM Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MCAM Human Pre-designed siRNA Set A contains three designed siRNAs for MCAM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24435

Mcam Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mcam Rat Pre-designed siRNA Set A contains three designed siRNAs for Mcam gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17964

Mcam Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mcam Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mcam gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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