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LO-3-61

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175179
    LO-3-61

    		Epigenetic Reader Domain E1/E2/E3 Enzyme Cancer
    LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells .
    LO-3-61

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