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Results for "

Kir2.1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (1) P-glycoprotein (1) Parasite (4) PKA (3) Potassium Channel (10) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (6) Infection (5) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173162

GPV0057	P-glycoprotein Potassium Channel	Cardiovascular Disease Cancer
GPV0057 (Compound 5d) is a selective and potent P-glycoprotein (P-gp) inhibitor. GPV0057 is also a selective potassium channel K_ir2.1 activator. GPV0057 competitively binds to the substrate-binding site of P-gp, inhibiting ATP-dependent drug efflux to reverse multidrug resistance in tumor cells. GPV0057 can also stabilizes the open state of K_ir2.1 and promotes potassium ion influx. GPV0057 is promising for research of tumors with high P-gp expression, K_ir2.1-deficient diseases such as heart failure and Andersen-Tawil Syndrome .

HY-118607

VU041	Potassium Channel Parasite	Infection
VU041 is a first submicromolar-affinity inhibitor of *Anopheles (An.) gambiae* and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC₅₀ values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian *Kir2.1* (IC₅₀ of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function .

HY-B1194

Tetramisole hydrochloride (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829	Potassium Channel Parasite PKA	Infection Cardiovascular Disease
Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC₅₀ of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure .

HY-112544

IK1 inhibitor PA-6 1 Publications Verification PA-6	Potassium Channel	Cardiovascular Disease
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent I_K1 (K_IR2.x ion-channel-carried inward rectifier current) inhibitor, with IC₅₀ values of 12-15 nM for human and mouse K_IR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates K_IR2.1 protein expression and induces intracellular K_IR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia .

HY-17442

Azathramycin Azaerythromycin A; Desmethyl Azithromycin	Bacterial Antibiotic	Infection
Azathramycin (Desmethyl Azithromycin) is a macrolide antibiotic. Azathramycin is a derivative of the anti-ribosomal antibiotic Azithromycin (HY-17506). Azathramycin exerts its antibacterial activity by binding to ribosomes and inhibiting bacterial protein synthesis. Azathramycin can selectively target and kill human senescent fibroblasts and is expected to be used in anti-aging research. Azathramycin affects multiple ion channels such as SCN5A, hERG, KCNQ1 + KCNE1, L-type Ca ⁺⁺ and K_ir2.1 .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-B1194A

Tetramisole	Potassium Channel Parasite PKA	Infection Cardiovascular Disease
Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC₅₀ of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure .

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-B1194R

Tetramisole hydrochloride (Standard) (±)-Tetramisole hydrochloride (Standard); DL-Tetramisole hydrochloride (Standard); R-829 (Standard)	Reference Standards Potassium Channel Parasite PKA	Infection Cardiovascular Disease
Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC₅₀ of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure .

HY-178058

VU6080824	Potassium Channel	Others
VU6080824 (Compound 5s), a derivative of ML-133 (HY-100230), is an inward-rectifier potassium channel (K_ir2.1) inhibitor with an IC₅₀ of 0.35  μM. VU6080824 has superior thallium flux and manual patch clamp (MPC) functional potency .

HY-RS26548

Kcnj2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kcnj2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnj2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kcnj2 Rat Pre-designed siRNA Set A Kcnj2 Rat Pre-designed siRNA Set A

HY-RS20045

Kcnj2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kcnj2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcnj2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kcnj2 Mouse Pre-designed siRNA Set A Kcnj2 Mouse Pre-designed siRNA Set A

HY-RS07145

KCNJ2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KCNJ2 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNJ2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KCNJ2 Human Pre-designed siRNA Set A KCNJ2 Human Pre-designed siRNA Set A

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

Cat. No.	Product Name	Target	Research Area

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83126

	Kir2.1 Antibody (YA2871) KCNJ2; ATFB9; HHBIRK1; IRK1; Kir2.1; LQT7; HIRK1; IRK-1; HHIRK1; SQT3	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Kir2.1 Antibody (YA2871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kir2.1.

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Cat. No.	Product Name		Classification

HY-RS26548

Kcnj2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kcnj2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnj2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20045

Kcnj2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kcnj2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcnj2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07145

KCNJ2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KCNJ2 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNJ2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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