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Results for "

KDM5A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (1) DNA/RNA Synthesis (1) Histone Demethylase (12) Histone Methyltransferase (1) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (13) Inflammation/Immunology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100014

KDM5A-IN-1 3 Publications Verification	Histone Demethylase	Cancer
KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 45 nM, 56 nM and 55 nM for *KDM5A, KDM5B* and *KDM5C, respectively, and with an EC₅₀* value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other *KDM5B* enzymes (1A, 2B, 3B, 4C, 6A, 7B) .

HY-102047B

KDOAM-25 citrate 5 Publications Verification	Histone Demethylase	Cancer
KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-123419

CPI-4203	Histone Demethylase	Cancer
CPI-4203 is a potent *KDM5A* inhibitor with an IC₅₀ of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent .

HY-119397A

KDM5-C49 hydrochloride KDOAM-20 hydrochloride	Histone Demethylase	Cancer
KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC₅₀s of 40 nM, 160 nM, and 100 nM for *KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5*-C49 hydrochloride can be used for the research of cancer .

HY-RS23099

Kdm5a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm5a Rat Pre-designed siRNA Set A Kdm5a Rat Pre-designed siRNA Set A

HY-RS16664

Kdm5a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm5a Mouse Pre-designed siRNA Set A Kdm5a Mouse Pre-designed siRNA Set A

HY-RS07218

KDM5A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM5A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM5A Human Pre-designed siRNA Set A KDM5A Human Pre-designed siRNA Set A

HY-102047

KDOAM-25	Histone Demethylase	Cancer
KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-102047A

KDOAM-25 trihydrochloride	Histone Demethylase	Cancer
KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-119397

KDM5-C49 KDOAM-20	Histone Demethylase	Cancer
KDM5-C49 (KDOAM-20) is a potent and selective inhibitor of KDM5 demethylases, with IC₅₀s of 40 nM, 160 nM, and 100 nM for *KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5*-C49 can be used for the research of cancer .

HY-100421

CPI-455 Maximum Cited Publications 7 Publications Verification	Histone Demethylase	Cancer
CPI-455 is a specific, pan-KDM5 inhibitor with an IC₅₀ of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .

HY-100421A

CPI-455 hydrochloride	Histone Demethylase	Cancer
CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC₅₀ of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .

HY-100764

YUKA1	Histone Demethylase	Cancer
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC₅₀ of 2.66 μM, less active on KDM5C (IC₅₀, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity .

HY-100624

Ryuvidine	CDK DNA/RNA Synthesis Histone Demethylase Histone Methyltransferase	Inflammation/Immunology Cancer
Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC₅₀ of 0.5 µM and suppresses monomethylation of H₄K₂₀. Ryuvidine also inhibits CDK4 with an IC₅₀ of 6.0 μM. Ryuvidine also inhibits *KDM5A* and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis ^[5].

HY-107573

KDM2/7-IN-1 1 Publications Verification	Histone Demethylase	Cancer
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase *KDM2/7* subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro .

HY-144501

D18	Toll-like Receptor (TLR) PD-1/PD-L1	Inflammation/Immunology Cancer
D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC₅₀=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 .

Species:	Human (2)
Tag:	Tag Free (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703589

	KDM5A Protein, Human JARID1A; RBBP2; RBP2	Human	E. coli
	KDM5A Protein, Human is the recombinant human-derived KDM5A, expressed by E. coli , with tag Free labeled tag. ,

HY-P702875

	KDM5A Protein, Human (sf9, Flag) JARID1A; RBBP2; RBP2	Human	Sf9 insect cells
	KDM5A Protein, Human (sf9, Flag) is the recombinant human-derived KDM5A, expressed by Sf9 insect cells , with C-Flag labeled tag. ,

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HY-P81819

	KDM5A Antibody (YA1564) JARID1A; KDM5A; RBBP2; RBP2	WB, ICC/IF, IP, FC	Human, Mouse
	KDM5A Antibody (YA1564) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1564), targeting KDM5A, with a predicted molecular weight of 192 kDa (observed band size: 192 kDa). KDM5A Antibody (YA1564) can be used for WB, ICC/IF, IP, FC experiment in human, mouse background.

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Kdm5a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kdm5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm5a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kdm5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM5A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KDM5A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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