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KB05yne

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-177554
    KB05yne

    		Biochemical Assay Reagents Cancer
    KB05yne is a site-selective, alkyne-functionalized electrophilic "scout" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type forms of target proteins (e.g., CDKN2AIP, HPCAL1) but not their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for site-specific covalent ligand discovery and optimization for structurally and functionally diverse proteins, particularly in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins .
    KB05yne

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