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Results for "

K399N

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178151
    CGR-51

    		RSV Infection
    CGR-51 is an orally active potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 19.4 nM against RSV A2 in HEp-2 cells). CGR-51 blocks RSV entry by binding to the F protein (KD = 0.1 μM) and inhibiting membrane fusion, a mechanism distinct from farnesyltransferase inhibition. CGR-51 selects for the K399N resistance mutation in the RSV F protein during in vitro passage. CGR-51 effectively suppresses RSV replication in a BALB/c mouse model of RSV infection. CGR-51 can be used for RSV infection research .
    CGR-51

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