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JP-2-196

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W854844A
    (E)-JP-2-196 TFA

    		E3 Ligase Ligand-Linker Conjugates Cancer
    JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders .
    (E)-JP-2-196 TFA
  • HY-W854844B
    JP-2-196 hydrochloride

    		Molecular Glues E1/E2/E3 Enzyme Cancer
    JP-2-196 hydrochloride is a covalent molecular glue degrader targeting RNF126. JP-2-196 hydrochloride induces the formation of a ternary complex between RNF126 and target proteins (e.g., BRD4, AR-V7), promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride is promising for research of cancers (e.g., prostate cancer, leukemia) .
    JP-2-196 hydrochloride

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