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JAK3-IN-18

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174999
    JAK3-IN-18

    		JAK Tyrosinase Neurological Disease Inflammation/Immunology
    JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis .
    JAK3-IN-18

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