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JAK2-IN-14

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175684
    JAK2-IN-14

    		JAK STAT Apoptosis Cancer
    JAK2-IN-14 is an orally active JAK2 inhibitor with an IC50 of 2 nM. JAK2-IN-14 demonstrates 89.5-, 80.5-, and 51-fold selectivity over JAK1, JAK3, and TYK2, respectively. JAK2-IN-14 inhibits STAT5 signaling pathway. JAK2-IN-14 causes tumor cell cycle arrest and apoptosis. JAK2-IN-14 can used for the study of myeloproliferative neoplasms (MPNs) .
    JAK2-IN-14

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