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Itraconazole

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By Targets:	Antibiotic (5) Autophagy (5) Bacterial (4) Cytochrome P450 (6) Drug Isomer (1) Drug Metabolite (4) Fungal (11) Hedgehog (5) HIV (1) Isotope-Labeled Compounds (2) Reference Standards (2)
By Research Areas:	Cancer (5) Infection (9)
Click Chemistry:	Azide (1)

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17514

*Itraconazole* 20+ Cited Publications R51211	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-12772

Hydroxy Itraconazole Itraconazole metabolite Hydroxy Itraconazole; R-63373	Fungal Drug Metabolite	Others
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-17514S2

Itraconazole-d9 R51211-d₉	Fungal Hedgehog Bacterial Autophagy Cytochrome P450 Antibiotic	Infection
Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17514S

Itraconazole-d5 R51211-d₅	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic	Infection Cancer
Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-17514S1

Itraconazole-d3 R51211-d₃	Antibiotic Autophagy Bacterial Cytochrome P450 Fungal Hedgehog	Infection Cancer
Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-117789

Keto-itraconazole keto-ITZ	Cytochrome P450	Infection Cancer
Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC₅₀ value of 4.6 nM when coincubated with human liver microsomes and midazolam .

HY-17514R

Itraconazole (Standard) R51211 (Standard)	Reference Standards Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial	Infection Cancer
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-12772R

*Hydroxy Itraconazole* (Standard)** Itraconazole metabolite Hydroxy Itraconazole (Standard); R-63373 (Standard)	Reference Standards Fungal Drug Metabolite	Others
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-12772A

rel-Hydroxy Itraconazole rel-R-63373	Drug Isomer	Infection
rel-Hydroxy Itraconazole (rel-R-63373) is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514) .

HY-12772S3

*Hydroxy Itraconazole-d6* R-63373-d₆	Isotope-Labeled Compounds Fungal	Others
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-12772S

*Hydroxy Itraconazole-d8* R-63373-d₈	Fungal	Infection
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-12772S1

*(2R,4S)-Hydroxy Itraconazole-d8* (2R,4S)-R-63373-d₈	Drug Metabolite Fungal Isotope-Labeled Compounds	Others
(2R,4S)-Hydroxy Itraconazole-d₈ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].

HY-12772S2

*(2R,4S)-Hydroxy Itraconazole-d5* (2R,4S)-R-63373-d₅	Drug Metabolite Fungal	Others
(2R,4S)-Hydroxy Itraconazole-d₅ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole .

HY-159150

HIV-1 inhibitor-71	HIV	Infection
HIV-1 inhibitor-71 (compound 2a) blocks the transport of endocytosed HIV-1 particles into nuclear envelope invagination (NEIs) that can inhibit productive infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17514

*Itraconazole* 20+ Cited Publications R51211	Microorganisms Source classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17514R

Itraconazole (Standard) R51211 (Standard)	Microorganisms Source classification	Reference Standards Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-17514S2

Itraconazole-d9
Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-17514S

Itraconazole-d5
Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-17514S1

Itraconazole-d3
Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

Itraconazole-d3

Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-12772S

*Hydroxy Itraconazole-d8*
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-12772S2

*(2R,4S)-Hydroxy Itraconazole-d5*
(2R,4S)-Hydroxy Itraconazole-d₅ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole .

HY-12772S3

*Hydroxy Itraconazole-d6*
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-12772S1

*(2R,4S)-Hydroxy Itraconazole-d8*
(2R,4S)-Hydroxy Itraconazole-d₈ is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].

Cat. No.	Product Name		Classification

HY-159150

HIV-1 inhibitor-71		Azide
HIV-1 inhibitor-71 (compound 2a) blocks the transport of endocytosed HIV-1 particles into nuclear envelope invagination (NEIs) that can inhibit productive infection .

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Itraconazole

Inhibitors & Agonists

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Isotope-Labeled Compounds

Click Chemistry

Natural
Products