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Isotope Applications

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Isotope-Labeled Compounds (1) Biochemical Assay Reagents (2) DNA-PK (1) Endogenous Metabolite (1) PSMA (2)
By Research Areas:	Cancer (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123733A

MIP-1095 TFA RPS-001 TFA	PSMA	Cancer
MIP-1095 (RPS-001) TFA is a potent inhibitor of PSMA with good biodistribution and efficient targeting of tumor lesions. In applications, MIP-1095 TFA will be isotopically labeled ( ¹³¹I labeled) as an imaging probe to indicate tumor progression. And ¹³¹I-MIP-1095 showed higher renal uptake in mice .

HY-158125

PSMA binder-2	PSMA	Cancer
PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with ¹¹¹In, it can be used as DOTA chelating agent and imaging agent. Or labeled with ²²⁵Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .

HY-158118

Lys(CO-C3-p-I-Ph)-OMe	DNA-PK	Cancer
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with ¹¹¹In, it can be used as DOTA chelating agent and imaging agent. Or labeled with ²²⁵Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .

HY-W088413A

DOTA-amide dihydrate	Biochemical Assay Reagents	Cancer
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs). DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer .

HY-131673

p-SCN-Bn-TCMC tetrahydrochloride	Biochemical Assay Reagents	Others
p-SCN-Bn-TCMC tetrahydrochloride is a bifunctional chelator that exhibits high reactivity due to its powerful TCMC component, making it effective for binding radio-isotopic heavy metal ions, which are essential in radio-diagnostic imaging applications.

HY-W585956

Triclocarban-13C6 3,4,4′-Trichlorocarbanilide-¹³C₆	Isotope-Labeled Compounds	Others
Triclocarban- ¹³C₆ is the ¹³C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-W750600

Acetonitrile-15N Methyl cyanide-¹⁵N	Endogenous Metabolite
Acetonitrile-15N (Methyl cyanide-15N) is a stable isotope labeled organic compound with important applications in metabolic research and molecular labeling. Acetonitrile-15N is used in biolabeling experiments to track metabolic pathways and help understand the chemical reaction mechanisms in organisms. Acetonitrile-15N is also widely used in environmental science to study the migration and transformation processes of pollutants.

Cat. No.	Product Name	Type

HY-W088413A

DOTA-amide dihydrate	Chelators
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs). DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer .

Cat. No.	Product Name	Chemical Structure

HY-W585956

Triclocarban-13C6
Triclocarban- ¹³C₆ is the ¹³C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

Triclocarban-13C6

Triclocarban- ¹³C₆ is the ¹³C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-W750600

Acetonitrile-15N
Acetonitrile-15N (Methyl cyanide-15N) is a stable isotope labeled organic compound with important applications in metabolic research and molecular labeling. Acetonitrile-15N is used in biolabeling experiments to track metabolic pathways and help understand the chemical reaction mechanisms in organisms. Acetonitrile-15N is also widely used in environmental science to study the migration and transformation processes of pollutants.

Acetonitrile-15N

Acetonitrile-15N (Methyl cyanide-15N) is a stable isotope labeled organic compound with important applications in metabolic research and molecular labeling. Acetonitrile-15N is used in biolabeling experiments to track metabolic pathways and help understand the chemical reaction mechanisms in organisms. Acetonitrile-15N is also widely used in environmental science to study the migration and transformation processes of pollutants.

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