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Isoniazid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Autophagy (4) Bacterial (10) Biochemical Assay Reagents (1) Drug Intermediate (1) Drug Metabolite (4) Endogenous Metabolite (5) GABA Receptor (2) Mitophagy (4) Phosphodiesterase (PDE) (1) Reference Standards (4)
By Research Areas:	Infection (12) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0329

*Isoniazid* 5+ Cited Publications INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide	Bacterial Autophagy Mitophagy Antibiotic	Infection
Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .

HY-B0329R

Isoniazid (Standard) INH (Standard); Isonicotinic acid hydrazide (Standard); Isonicotinic hydrazide (Standard)	Reference Standards Bacterial Autophagy Mitophagy Antibiotic	Infection
Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .

HY-B0329S

Isoniazid-d4 INH-d₄; Isonicotinic acid hydrazide-d₄; Isonicotinic hydrazide-d₄	Bacterial Autophagy Mitophagy Antibiotic	Infection
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .

HY-101059

FGIN 1-27	GABA Receptor	Neurological Disease
FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a K_i of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions .

HY-I0736

Isonicotinic acid	Drug Metabolite Endogenous Metabolite	Others
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-161542

Isoniazid/BSA	Biochemical Assay Reagents	Inflammation/Immunology
Isoniazid/BSA is an antigen-adjuvant conjugate of Isoniazid (HY-B0329) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.

HY-158289

Isoniazid-KLH	Antibiotic Mitophagy Autophagy Bacterial	Inflammation/Immunology
Isoniazid-KLH is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-117492

Aconiazide Isonicophen	Bacterial	Infection
Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis .

HY-157870

Mtb-IN-6	Bacterial	Infection
Mtb-IN-6 (Compound C10) is a Mycobacterium tuberculosis(*Mtb) respiration inhibitor. Mtb-IN-6 can enhance the bactericidal activity of isoniazid* (INH, HY-B0329). Mtb-IN-6 inhibits WT Mtb with an IC₅₀ of 25 µM .

HY-101059R

FGIN 1-27 (Standard)	GABA Receptor Reference Standards	Neurological Disease
FGIN 1-27 (Standard) is the analytical standard of FGIN 1-27. This product is intended for research and analytical applications. FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions .

HY-I0736S

Isonicotinic acid-d4	Drug Metabolite Endogenous Metabolite	Others
Isonicotinic acid-d₄ is the deuterium labeled Isonicotinic acid . Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-I0736R

Isonicotinic acid (Standard)	Reference Standards Drug Metabolite Endogenous Metabolite	Others
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Drug Intermediate Reference Standards	Others
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-100048

Acetylisoniazid AcINH	Drug Metabolite	Infection
Acetylisoniazid is a primary Isoniazid (HY-B0329) metabolite mediated by N-acetyltransferase (NAT). Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .

HY-145525

Linoleoyl-L-carnitine chloride CAR 18:2; C18:2 Carnitine; L-Carnitine linoleoyl ester	Endogenous Metabolite	Others
Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of Isoniazid (Item No. 20378) in mice.

HY-147263

Dovramilast CC-11050	Phosphodiesterase (PDE)	Infection Inflammation/Immunology
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB) .

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) .

HY-155722

Mtb-IN-5	Bacterial	Infection
Mtb-IN-5 (compound (-)17j) is an isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity. Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .

HY-155720

Mtb-IN-4	Bacterial	Infection
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC₅₀=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .

HY-158380

UH-NIP-16	Bacterial	Infection
UH-NIP-16 exhibits antimicrobial activity against Mycobacterium tuberculosis, with MIC₅₀ of 1.86 and 3.05 μM, for pathogenic mycobacterial strains H37Rv and CDC1551. UH-NIP-16 synergizes with Streptomycin (HY-B1906), Isoniazid (HY-B0329), Ethambutol (HY-B0535) and Bedaquiline (HY-14881), potentiates their anti-tuberculosis activities .

HY-175016

NADH-IN-3	Endogenous Metabolite	Infection Metabolic Disease
NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) .

Cat. No.	Product Name

HY-L142

Anti-tuberculosis Compound Library	126 compounds
Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases. Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs. MCE supplies a unique collection of 126 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Anti-tuberculosis Compound Library

126 compounds

Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases.

Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs.

MCE supplies a unique collection of 126 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Cat. No.	Product Name	Type

HY-161542

Isoniazid/BSA	Biochemical Assay Reagents
Isoniazid/BSA is an antigen-adjuvant conjugate of Isoniazid (HY-B0329) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.

HY-158289

Isoniazid-KLH	Biochemical Assay Reagents
Isoniazid-KLH is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Biochemical Assay Reagents
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-I0736

Isonicotinic acid	Alkaloids Aloe africana Liliaceae Source classification Other Diseases Pyridine Alkaloids Plants Disease Research Fields	Drug Metabolite Endogenous Metabolite
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-I0736R

Isonicotinic acid (Standard)	Alkaloids Aloe africana Liliaceae Source classification Pyridine Alkaloids Plants	Reference Standards Drug Metabolite Endogenous Metabolite
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Intermediate Reference Standards
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

Cat. No.	Product Name	Chemical Structure

HY-B0329S

Isoniazid-d4
Isoniazid-d₄ is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .

HY-I0736S

Isonicotinic acid-d4
Isonicotinic acid-d₄ is the deuterium labeled Isonicotinic acid . Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

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Isoniazid

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products