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Results for "

Isocoumarin

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

7

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W510159
    5-O-Methylembelin

    		PCSK9 Cardiovascular Disease
    5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .
    5-O-Methylembelin
  • HY-13705
    NM-3

    		Apoptosis MDM-2/p53 Cardiovascular Disease Inflammation/Immunology
    NM-3 is an isocoumarin with antiarthritic and antiangiogenic effects. NM-3 is an orally active antiangiogenic agent with low toxicity .
    NM-3
  • HY-N2831
    Agrimonolide 6-O-β-D-glucoside

    		Others Others
    Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research .
    Agrimonolide 6-O-β-D-glucoside
  • HY-N6294
    Monocerin

    		Bacterial Fungal Infection
    Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
    Monocerin
  • HY-W751002
    Orthosporin

    (+)-Orthosporin

    		 Endogenous Metabolite Bacterial HIV Reverse Transcriptase Infection
    Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .
    Orthosporin
  • HY-N13291
    6-O-Methylreticulol

    		Fungal Others
    6-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China .
    6-O-Methylreticulol
  • HY-N10702
    PCSK9-IN-9

    		PCSK9 Cardiovascular Disease
    PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM .
    PCSK9-IN-9
  • HY-147950
    PDE4-IN-10

    		Phosphodiesterase (PDE) TNF Receptor Inflammation/Immunology
    PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro .
    PDE4-IN-10
  • HY-115913
    PDE4-IN-6

    		Phosphodiesterase (PDE) Inflammation/Immunology
    PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .
    PDE4-IN-6
  • HY-N16371
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid

    		Endogenous Metabolite Inflammation/Immunology Cancer
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid (Compound MC-1), an isocoumarin, is a metabolite of Cytogenin (HY-19606). 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid has anti-angiogenic activity in S-180 implanted dorsal air sac mice model. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid also modifies collagen-induced arthritis. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid can be used for cancers and inflammatory diseases research .
    6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid

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