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Results for "

Indoline

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) Apoptosis (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Fluorescent Dye (2) HIV (1) Isotope-Labeled Compounds (1) JAK (1) Monoamine Oxidase (2) P2X Receptor (1) Potassium Channel (3) Reference Standards (3) Serotonin Transporter (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (3) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0788

*Indoline*	HIV	Infection
Indoline is a derivative of Indole (HY-W001132). Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1_AD8 with an IC₅₀ in the micromolar range .

HY-Y0265

Isatin Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Cardiovascular Disease Neurological Disease Cancer
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-50938

D149 Dye D149; Indoline dye D149	Fluorescent Dye	Others
D149 Dye is an indoline-based dye, which is a high-extinction-coefficient metal-free organic sensitizer.

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Reference Standards Monoamine Oxidase Apoptosis	Cardiovascular Disease Neurological Disease Cancer
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-W247614

D 131	Fluorescent Dye	Others
D 131 is an orange organic indoline dye. The absorption maxima of D131 in solution is λ=425 nm .

HY-129568

Tetraphyllicine	Others	Others
Tetraphyllicine is an alkaloid, which can be isolated from Rauwolfia tetraphylla L. Tetraphyllicine can be used in research about the biosynthetic relationship of indole and indoline alkaloids .

HY-W394903R

GS-829845 (Standard)	Reference Standards JAK Drug Metabolite	Cancer
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-W408830

4-Iodobutyl benzoate	Biochemical Assay Reagents	Others
4-Iodobutyl benzoate is structurally related to bicyclic heterocycles such as indole and indoline. 4-Iodobutyl benzoate is a metabolite of the drug amide and is used in the treatment of inflammatory bowel disease, degenerative diseases, and bowel disease.

HY-125047

Daledalin tosylate UK 3557 tosylate	Adrenergic Receptor Serotonin Transporter	Neurological Disease
Daledalin tosylate is an orally active indoline antidepressant targeting noradrenaline and serotonin transporters in the brain. Daledalin tosylate enhances central monoaminergic neurotransmission to alleviate depressive symptoms. Daledalin tosylate is proming for rasearch of depression, including endogenous and neurotic depression .

HY-125047A

Daledalin UK 3557	Serotonin Transporter Adrenergic Receptor	Neurological Disease
Daledalin (UK 3557) is an orally active indoline antidepressant targeting noradrenaline and serotonin transporters in the brain. Daledalin enhances central monoaminergic neurotransmission to alleviate depressive symptoms. Daledalin is proming for rasearch of depression, including endogenous and neurotic depression .

HY-W420344

Dehydroindapamide	Potassium Channel	Others
Dehydroindapamide is the indole form of Indapamide (HY-B0259). Dehydroindapamide standard can be used to quantitatively measure the Indapamide turnover rate by CYP3A4, which was approximately 10-fold higher than that of Indoline (HY-Y0788), and slightly enhanced affinity for CYP3A4 .

HY-117119

VER-3323	5-HT Receptor	Metabolic Disease
VER-3323 is an oral active 5-HT_2C agonist and belongs to the class of indoline analogs. VER-3323 reduces food intake in rats by inducing swallowing dysfunction, with no significant impact on energy expenditure generated through thermogenesis or exercise. VER-3323 can be utilized in obesity research .

HY-119642

Kopsinine	Others	Others
Kopsinine is an indole alkaloid extracted from periwinkle flowers .

HY-116788

Lipofermata 4 Publications Verification	Bacterial	Infection
Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC₅₀ of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM .

HY-W420344R

Dehydroindapamide (Standard)	Potassium Channel Reference Standards	Others
Dehydroindapamide (Standard) is the analytical standard of Dehydroindapamide. This product is intended for research and analytical applications. Dehydroindapamide is the indole form of Indapamide (HY-B0259). Dehydroindapamide standard can be used to quantitatively measure the Indapamide turnover rate by CYP3A4, which was approximately 10-fold higher than that of Indoline (HY-Y0788), and slightly enhanced affinity for CYP3A4 .

HY-144470S

Dehydroindapamide-d3	Isotope-Labeled Compounds Potassium Channel	Others
Dehydroindapamide-d₃ is the deuterium labeled Dehydroindapamide (HY-W420344). Dehydroindapamide is the indole form of Indapamide (HY-B0259). Dehydroindapamide standard can be used to quantitatively measure the Indapamide turnover rate by CYP3A4, which was approximately 10-fold higher than that of Indoline (HY-Y0788), and slightly enhanced affinity for CYP3A4 .

HY-115929

DENV-IN-4	DNA/RNA Synthesis	Infection
DENV-IN-4 is a potent DENV inhibitor (DENV EC₅₀=4.79 μM, Vero CC₅₀>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect .

HY-134807

Indophagolin	P2X Receptor 5-HT Receptor Autophagy	Cancer
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC₅₀=140 nM). Indophagolin antagonizes the purinergic receptor P2X₄ as well as P2X₁ and P2X₃ with IC₅₀s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the G_q-protein-coupled P2Y₄, P2Y₆, and P2Y₁₁ receptors (IC₅₀s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT₆ (IC₅₀=1.0 μM) and a moderate effect on receptors 5-HT_1B, 5-HT_2B, 5-HT_4e, and 5-HT₇ .

Cat. No.	Product Name

HY-L0107V

Life Chemicals Natural Product-like Compound Library	13,236 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

Life Chemicals Natural Product-like Compound Library

13,236 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.

Cat. No.	Product Name	Type