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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

IgG4 κ monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

45

Inhibitory Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99453
    Azintuxizumab

    		ADC Antibody Cancer
    Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .
    Azintuxizumab
  • HY-P990737
    Eltrekibart

    LY-3041658

    		 CXCR Inflammation/Immunology
    Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Eltrekibart
  • HY-P990773
    Venanprubart

    LY-3361237

    		 CD28 Inflammation/Immunology
    Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Venanprubart
  • HY-P990726
    Abiprubart

    		TNF Receptor Inflammation/Immunology
    Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Abiprubart
  • HY-P991166
    Ubletamig

    		Mucin Others
    Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    Ubletamig
  • HY-P991117
    Amrecibart

    		Factor Xa Cardiovascular Disease
    Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    Amrecibart
  • HY-P991169
    Zemocimig

    		Factor Xa Cardiovascular Disease
    Zemocimig is an anti-coagulation factor F9 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    Zemocimig
  • HY-P990758
    Reflocibart

    		VEGFR Inflammation/Immunology
    Reflocibart is an anti-VEGFB human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Reflocibart
  • HY-P990755
    Pamvatamig

    		EGFR Inflammation/Immunology
    Pamvatamig is an anti-EGFR/MET human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Pamvatamig
  • HY-P990702
    Pradusinstobart

    LVGN-3616

    		 PD-1/PD-L1 Inflammation/Immunology
    Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Pradusinstobart
  • HY-P990750
    Negalstobart

    		LAG-3 Inflammation/Immunology
    Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Negalstobart
  • HY-P990761
    Roconkibart

    		Interleukin Related Inflammation/Immunology
    Roconkibart is an anti-IL17A human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Roconkibart
  • HY-P991340
    CT140

    		PAI-1 Cardiovascular Disease
    CT140 is a human IgG4 monoclonal antibody (mAb) targeting PAI-1. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    CT140
  • HY-P990777
    Vipalanebart

    		Small Interfering RNA (siRNA) Inflammation/Immunology
    Vipalanebart is an anti-ADCYAP1R human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Vipalanebart
  • HY-P990751
    Nelmastobart

    		Transmembrane Glycoprotein Inflammation/Immunology
    Nelmastobart is an anti-BTN1A1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Nelmastobart
  • HY-P990752
    Nezastomig

    REGN-5678

    		 CD28 Inflammation/Immunology
    Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Nezastomig
  • HY-P990691
    Vilamakitug

    XB-2001

    		 Interleukin Related Inflammation/Immunology
    Vilamakitug (XB-2001) is an anti-IL-1α human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Vilamakitug
  • HY-P990692
    Ciduvectamig

    		CD3 Inflammation/Immunology
    Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ciduvectamig
  • HY-P991171
    Anti-CD4 Antibody (Hu5A8)

    		Transmembrane Glycoprotein Inflammation/Immunology
    Anti-CD4 Antibody (Hu5A8) is a humanized IgG4 monoclonal antibody that targets CD4. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Anti-CD4 Antibody (Hu5A8)
  • HY-P991489
    ENx-108A

    		Interleukin Related Inflammation/Immunology
    ENx-108A is a human IgG4 monoclonal antibody (mAb) targeting IL-11. BI-765423 can be used in fibrotic diseases research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
    ENx-108A
  • HY-P990072
    Lipustobart

    LZM-009

    		 PD-1/PD-L1 Cancer
    Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
    Lipustobart
  • HY-P990070
    Zigakibart

    BION-1301

    		 TNF Receptor Inflammation/Immunology Cancer
    Zigakibart (BION-1301) is an IgG4-kappa, anti-TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256) humanized monoclonal antibody. Zigakibart shows anti-inflammatory activity .
    Zigakibart
  • HY-P991301
    IMP-761

    		LAG-3 Cancer
    IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    IMP-761
  • HY-P99971
    Gemtuzumab

    		ADC Antibody Transmembrane Glycoprotein Cancer
    Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Gemtuzumab
  • HY-P99389
    Tesnatilimab

    JNJ-64304500; IPH-2301; NN-8555

    		 C-type Lectin-like Receptors (CTLRs) Inflammation/Immunology
    Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D. Tesnatilimab can be studied in research for diseases such as Crohn’s disease (CD) and Inflammatory Bowel Disease (IBD). Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Tesnatilimab
  • HY-P991183
    SAR-442257

    		CD28 CD38 CD3 Cancer
    SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .
    SAR-442257
  • HY-P991393
    ASP8374

    		Transmembrane Glycoprotein IFNAR TNF Receptor Cancer
    ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
    ASP8374
  • HY-P991067
    Vensobafusp alfa

    KP-104

    		 Complement System Inflammation/Immunology
    Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .
    Vensobafusp alfa
  • HY-P991253
    BIIB022

    		IGF-1R Cancer
    BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting IGF1R/CD221. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
    BIIB022
  • HY-P991070
    ADG-106

    		TNF Receptor Cancer
    ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    ADG-106
  • HY-P991201
    REGN-7257

    		Interleukin Related Inflammation/Immunology
    REGN-7257 is a humanized monoclonal antibody targeting IL2RG that effectively blocks signaling of all γ-c cytokines. REGN-7257 can be used in the study of aplastic anemia. The corresponding isotype control is: Human IgG4 kappa, Isotype Control (HY-P99003) .
    REGN-7257
  • HY-P990091
    Riliprubart

    SAR 445088

    		 Complement System Inflammation/Immunology
    Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Riliprubart
  • HY-P9971
    Camrelizumab
    4 Publications Verification

    SHR-1210

    		 PD-1/PD-L1 Cancer
    Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
    Camrelizumab
  • HY-P99613
    Favezelimab

    MK-4280

    		 LAG-3 Cancer
    Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand MHC class II. Favezelimab has the potential for colorectal cancer (CRC) research in combination with the PD-L1 inhibitor Pembrolizumab (HY-P9902). Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Favezelimab
  • HY-P991452
    Anti-CD200R1/OX2R Antibody (I-4P)

    		Orexin Receptor (OX Receptor) Cancer
    Anti-CD200R1/OX2R Antibody (I-4P) is a human monoclonal antibody (mAb) targeting CD200R1/OX2R. Anti-CD200R1/OX2R Antibody (I-4P) can be used in solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
    Anti-CD200R1/OX2R Antibody (I-4P)
  • HY-P99668
    Iparomlimab

    		PD-1/PD-L1 Cancer
    Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
    Iparomlimab
  • HY-P99299
    Lexatumumab

    HGS-ETR 2; ETR2-ST01

    		 Apoptosis Cancer
    Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
    Lexatumumab
  • HY-P991574
    MEDI-5884

    REG-101

    		 ATGL Cardiovascular Disease
    MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting Endothelial lipase (EL). MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins (HDL). MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research .
    MEDI-5884
  • HY-P991620
    JS006

    		Transmembrane Glycoprotein Cancer
    JS006 is a humanized IgG4κ monoclonal antibody inhibitor targeting TIGIT/CD155. JS006 can be used to study advanced and/or metastatic cancers with resistance to PD-1/PD-L1 inhibitor such as non-small cell lung cancer (NSCLC), advanced lymphoma and advanced/metastatic triple negative breast cancer (TNBC) .
    JS006

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