Glutamate decarboxylase

By Targets:	Amino Acid Decarboxylase (4) Amino Acid Derivatives (1) Bacterial (3) Caspase (2) Endogenous Metabolite (5) GABA Receptor (4) LPL Receptor (1) NF-κB (2)
By Research Areas:	Cancer (2) Infection (3) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (3)

Targets Recommended: Glutamate Dehydrogenase (GLDH) Amino Acid Decarboxylase Ornithine decarboxylase (ODC) Malonyl-CoA Decarboxylase mGluR iGluR EAAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2553

4-Deoxypyridoxine 5'-phosphate	LPL Receptor	Metabolic Disease
4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a K_i of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (K_i of 0.27 μM) and strongly inhibits glutamate-dependent labeling of **glutamate decarboxylase** .

HY-Y0367

Maleic Acid 1 Publications Verification	Endogenous Metabolite Bacterial	Infection
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-Y0367S

Maleic Acid-d2 Maleic-2,3-d2 acid	Bacterial Endogenous Metabolite	Infection
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

HY-W016349

Chelidamic acid	Amino Acid Decarboxylase	Others
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K_i of 33 μM.

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Endogenous Metabolite Amino Acid Decarboxylase	Metabolic Disease Inflammation/Immunology
(Z)-Aconitic acid is an orally active **glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α** phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a **glutamate decarboxylase inhibitor, with a K_i** of 1.2 μM .

HY-E70570

**Glutamate decarboxylase**	GABA Receptor	Metabolic Disease
Glutamate decarboxylase is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). Many gut microbes can metabolize glutamate via their Glutamate decarboxylase in a pyridoxal-5′-phosphate (PLP) dependent manner .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

HY-W016814R

(Z)-Aconitic acid (Standard)	Endogenous Metabolite	Others
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a **glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α** phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W041489R

Chelidonic acid (Standard)	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-Y0367R

Maleic Acid (Standard)	Endogenous Metabolite Bacterial	Infection
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

Cat. No.	Product Name	Target	Research Area

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0367

Maleic Acid 1 Publications Verification	Infection Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite Amino Acid Decarboxylase
(Z)-Aconitic acid is an orally active **glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α** phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a **glutamate decarboxylase inhibitor, with a K_i** of 1.2 μM .

HY-W016814R

(Z)-Aconitic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a **glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α** phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W041489R

Chelidonic acid (Standard)	Structural Classification Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Papaveraceae	NF-κB Caspase
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-Y0367R

Maleic Acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Bacterial
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

Species:	Human (3) Mouse (2)
Tag:	His (3) Tag Free (1) GST (2)
Source:	Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70294

	Glutamine synthetase/GLUL Protein, Human (His) rHuGlutamine synthetase/GLUL, His; Glutamine Synthetase; GS; Glutamate decarboxylase; Glutamate--Ammonia Ligase; GLUL; GLNS	Human	E. coli
	GLUL proteins catalyze the conversion of glutamate and ammonia to glutamine. Glutamine synthetase/GLUL Protein, Human (His) is the recombinant human-derived Glutamine synthetase/GLUL protein, expressed by E. coli , with C-6*His labeled tag.

HY-P75178

	GAD2/GAD65 Protein, Mouse (sf9) Glutamate decarboxylase 2; GAD-65; GAD2	Mouse	Sf9 insect cells
	GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with tag free.

HY-P75179

	GAD2/GAD65 Protein, Human (sf9, GST) Glutamate decarboxylase 2; GAD-65; GAD2	Human	Sf9 insect cells
	GAD2/GAD65 proteins are key enzymes in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). GABA is an important inhibitory neurotransmitter in the central nervous system, playing a key role in regulating neuronal excitability and maintaining the balance between excitation and inhibition in the brain. GAD2/GAD65 Protein, Human (sf9, GST) is the recombinant human-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P75177

	GAD2/GAD65 Protein, Mouse (sf9, His-GST) Glutamate decarboxylase 2; GAD-65; GAD2	Mouse	Sf9 insect cells
	GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75180

	GAD1/GAD67 Protein, Human (sf9, His) Glutamate decarboxylase 1; GAD-67; GAD1; GAD	Human	Sf9 insect cells
	The GAD1/GAD67 protein utilizes pyridoxal 5'-phosphate as a cofactor and acts as a catalyst in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GAD1 plays a key role in the conversion of glutamate to GABA, a key neurotransmitter involved in regulating neuronal excitability. GAD1/GAD67 Protein, Human (sf9, His) is the recombinant human-derived GAD1/GAD67 protein, expressed by Sf9 insect cells , with C-His labeled tag.

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HY-Y0367S

Maleic Acid-d2
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85817

	Glutamine synthetase Antibody (YA5509) GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase	WB, ICC/IF, ELISA, IHC-P	Human, Mouse, Rat,

HY-P86524

	Glutamine Synthetase Antibody (YA6216) GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat,

HY-P82062

	GAD67 Antibody (YA1807) Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67	WB, IP	Human
	GAD67 Antibody (YA1807) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1807), targeting GAD67, with a predicted molecular weight of 67 kDa (observed band size: 67 kDa). GAD67 Antibody (YA1807) can be used for WB, IP experiment in human background.

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Glutamate decarboxylase

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