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Results for "

GRN

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

4

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P4073
    ANG1005

    GRN1005; Paclitaxel trevatide

    		 Peptide-Drug Conjugates (PDCs) LDLR Cancer
    ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .
    ANG1005
  • HY-P99688
    Latozinemab

    AL001

    		 Neurotensin Receptor Cancer
    Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .
    Latozinemab
  • HY-115733
    Cathepsin L-IN-2

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L/B inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-124393
    GRN-529

    		mGluR Neurological Disease
    GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats .
    GRN-529
  • HY-RS05843
    GRN Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GRN Human Pre-designed siRNA Set A contains three designed siRNAs for GRN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GRN Human Pre-designed siRNA Set A
    GRN Human Pre-designed siRNA Set A
  • HY-RS24139
    Grn Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Grn Rat Pre-designed siRNA Set A contains three designed siRNAs for Grn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Grn Rat Pre-designed siRNA Set A
    Grn Rat Pre-designed siRNA Set A
  • HY-RS17678
    Grn Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA)
    Grn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Grn Mouse Pre-designed siRNA Set A
    Grn Mouse Pre-designed siRNA Set A
  • HY-12854
    Imetelstat

    GRN163L

    		 Telomerase Cancer
    Imetelstat is an 13‐mer oligonucleotide that binds with high affinity to the template region of the RNA component of human telomerase and acts as a competitive inhibitor of human telomerase enzymatic activity .
    Imetelstat

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