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FaDu

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Apoptosis (8) Bacterial (1) Bcl-2 Family (1) BCRP (1) Beta-secretase (3) Biochemical Assay Reagents (2) Caspase (1) Chloride Channel (1) DNA-PK (1) Drug Derivative (1) EGFR (1) Endogenous Metabolite (3) JNK (1) Microtubule/Tubulin (1) MMP (1) nAChR (1) p38 MAPK (1) PI3K (1) PROTACs (2) Proteasome (1) Ras (1) Survivin (1) TGF-β Receptor (1)
By Research Areas:	Cancer (20) Infection (1) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W272058

Isometronidazole	Others	Cancer
Isometronidazole is a hypoxic cell sensitizer. Isometronidazole (750 mg/kg) shows an efficacy as a hypoxic cell sensitizer in severely hypoxic FaDu tumors but not in less hypoxic GL tumors.

HY-160438B

PBX-7011 TFA	Bcl-2 Family Survivin	Cancer
PBX-7011 TFA is a derivative of camptothecin (HY-16560), which inhibits expressions of the cancer related survival genes DDX5, Survivin, Mcl-1 and XIAP in cells FaDu, degrades DDX5 proteins and exhibits anticancer activity .

HY-22024

5-Hydroxyflavone	Others	Cancer
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-B0942

Benzethonium chloride	nAChR Bacterial Apoptosis Caspase	Infection Neurological Disease Cancer
Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo .

HY-P99676

Izalontamab SI-B001	EGFR	Cancer
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer .

HY-W272058R

Isometronidazole (Standard)	Biochemical Assay Reagents	Cancer
Isometronidazole (Standard) is the analytical standard of Isometronidazole. This product is intended for research and analytical applications. Isometronidazole is a hypoxic cell sensitizer. Isometronidazole (750 mg/kg) shows an efficacy as a hypoxic cell sensitizer in severely hypoxic FaDu tumors but not in less hypoxic GL tumors.

HY-169134

PROTAC 20S proteasome subunit β5 degrader 1	PROTACs Apoptosis	Cancer
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) is a targeted degrader of PROTAC for 20S proteasome subunit β5, with a DC₅₀ value of 0.11 μM in FaDu cells. PROTAC 20S proteasome subunit β5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit β5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib (HY-10227) (Pink: Target protein ligand (HY-10227); Blue: E3 ligase ligand (HY-103596); Black: Linker (HY-169142)) .

HY-169135

PROTAC 20S proteasome subunit β5 degrader 2	PROTACs Proteasome	Cancer
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC₅₀ of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC₅₀ of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models . (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

HY-173405

VVD-699	Ras PI3K	Cancer
VVD-699 is a covalent RAS-PI3K inhibitor. VVD-699 covalently binds to cysteine 242 in the RAS binding domain of PI3K p110α, thereby blocking the ability of RAS to activate PI3K activity. VVD-699 is able to inhibit the growth of RAS-mutated and HER2-overexpressing tumors. VVD-699 can be used to study cancers associated with RAS mutations (e.g., H358 lung cancer cells, A549 cells, FaDu cells) .

HY-161248

E7130	Microtubule/Tubulin	Cancer
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .

HY-101570

Nedisertib Maximum Cited Publications 20 Publications Verification Peposertib; M3814	DNA-PK BCRP	Cancer
Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .

HY-125006

TRi-1 3 Publications Verification	JNK p38 MAPK	Cancer
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC₅₀ of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy .

HY-12692

DO3A tert-Butyl ester DO3A tert-butyl; DO3A-t-Bu-ester	Drug Derivative	Cancer
DOTA tert-Butyl ester is a cyclic tosamide benzyl derivative.

HY-146029

Apoptosis inducer 3	Apoptosis	Cancer
Apoptosis inducer 3 (Compound 3) is an apoptosis inducer that selectively triggers apoptosis and late-apoptosis. Apoptosis inducer 3 shows cytotoxicity against cancer cells .

HY-147874

ANO1-IN-3	Chloride Channel Apoptosis	Cancer
ANO1-IN-3 (Compound 3n) is a potent and selective ANO1 inhibitor with an IC₅₀ of 1.23 μM. ANO1-IN-3 induces apoptosis .

HY-B1260

Cetrimonium bromide 1 Publications Verification CTAB; Cetyltrimethylammonium bromide; Hexadecyltrimethylammonium bromide	Biochemical Assay Reagents MMP Apoptosis TGF-β Receptor	Cancer
Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction .

HY-114245R

Se-Methylselenocysteine (Standard)	Apoptosis Endogenous Metabolite Beta-secretase	Cancer
Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0

HY-114245B

Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride	Endogenous Metabolite Apoptosis Beta-secretase	Cancer
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis .

HY-114245

Se-Methylselenocysteine 2 Publications Verification Methylselenocysteine; Se-Methylseleno-L-cysteine	Apoptosis Endogenous Metabolite Beta-secretase	Cancer
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis .

HY-P99719

Lupartumab Amadotin BAY 1129980; Anti-C4.4a antibody-drug conjugates	Antibody-Drug Conjugates (ADCs)	Cancer
Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human C4.4A (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .

Cat. No.	Product Name	Target	Research Area

HY-P99676

Izalontamab SI-B001	EGFR	Cancer
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer .

HY-P99719

Lupartumab Amadotin BAY 1129980; Anti-C4.4a antibody-drug conjugates	Antibody-Drug Conjugates (ADCs)	Cancer
Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human C4.4A (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .

5-Hydroxyflavone	Flavonoids Monophenols other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Cancer	Others
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

Se-Methylselenocysteine 2 Publications Verification Methylselenocysteine; Se-Methylseleno-L-cysteine	Structural Classification other families Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Beta-secretase
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis .

Se-Methylselenocysteine (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Plants	Apoptosis Endogenous Metabolite Beta-secretase
Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0

Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis Beta-secretase
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis .

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FaDu

Inhibitors & Agonists

Inhibitory Antibodies

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Natural
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