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Results for "

FXR agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FXR (67) Akt (1) Aminotransferases (Transaminases) (1) AMPK (1) Antibiotic (1) Apoptosis (5) Autophagy (19) Bacterial (1) Calcium Channel (1) Cytochrome P450 (2) Endogenous Metabolite (2) ERK (1) Estrogen Receptor/ERR (1) Ferroptosis (1) G protein-coupled Bile Acid Receptor 1 (5) Glutathione Reductase (GR) (1) HBV (1) Insecticide (2) Isotope-Labeled Compounds (1) LXR (2) mTOR (1) p38 MAPK (1) PD-1/PD-L1 (1) Phosphatase (1) PI3K (1) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) ROR (2) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (6) Infection (4) Inflammation/Immunology (30) Metabolic Disease (30) Neurological Disease (2)

By Targets:

FXR (67)

Akt (1)

Aminotransferases (Transaminases) (1)

AMPK (1)

Antibiotic (1)

Apoptosis (5)

Autophagy (19)

Bacterial (1)

Calcium Channel (1)

Cytochrome P450 (2)

Endogenous Metabolite (2)

ERK (1)

Estrogen Receptor/ERR (1)

Ferroptosis (1)

G protein-coupled Bile Acid Receptor 1 (5)

Glutathione Reductase (GR) (1)

HBV (1)

Insecticide (2)

Isotope-Labeled Compounds (1)

LXR (2)

mTOR (1)

p38 MAPK (1)

PD-1/PD-L1 (1)

Phosphatase (1)

PI3K (1)

PPAR (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

ROR (2)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (6)

Infection (4)

Inflammation/Immunology (30)

Metabolic Disease (30)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: FXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153525

FXR agonist 5	FXR	Metabolic Disease Inflammation/Immunology
FXR agonist 5 (compound 1) is a *FXR* agonist. FXR agonist 5 can be used for research in diseases or disorders caused by metabolic inflammation .

HY-151932

FXR agonist 3	FXR	Inflammation/Immunology
FXR agonist 3 is an anti-NASH agent, acting by activating *FXR. FXR* agonist 3 inhibits COL1A1, TGF-β1, α-SMA and TIMP1 expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level .

HY-163466

FXR agonist 7	FXR	Inflammation/Immunology
FXR agonist 7 (compound 33) is a potent agonist of *FXR, with EC₅₀* of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity .

HY-168331

FXR agonist 10	FXR	Others
FXR agonist 10 (Compound 27) is an agonist for *FXR* with an EC₅₀ of 14.26 μM. FXR agonist 10 upregulates the expression of SHP and BSEP proteins, downregulates the expression of NTCP and CYP7A1 proteins. FXR agonist 10 ameliorates the ANIT-induced cholestasis in mouse model .

HY-164799

FXR agonist 12	FXR	Inflammation/Immunology
FXR agonist 12 (Compound C7) is the orally active agonist for *FXR. FXR* agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models .

HY-151959

FXR agonist 4	FXR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC₅₀ value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .

HY-168332

FXR agonist 11	FXR	Metabolic Disease
FXR agonist 11 (Compound 14) is an *FXR* agonist with an EC₅₀ of 1.2 μM and a maximum effect of 73.7%. FXR agonist 11 can significantly increase GSH levels in the liver and is used to study drug-induced liver injury diseases .

HY-168629

FXR agonist 9	FXR	Metabolic Disease
FXR agonist 9 (compound 26) is an oral active and selectivity *FXR* partial agonist with the EC₅₀ of 0.09 µM (75.13 % maximum efficacy). FXR agonist 9 ameliorates pathological features in HFD and CCl₄(HY-Y0298)-induced metabolic dysfunction-associated steatohepatitis mice .

HY-175516

*dual FXR/PPARδ agonist-2*	FXR PPAR	Inflammation/Immunology
dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC₅₀ of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model .

HY-142159

FXR/TGR5 agonist 1	FXR G protein-coupled Bile Acid Receptor 1	Metabolic Disease
FXR/TGR5 agonist 1 has agonist action on *FXR* and TGR5, and can be used for the research of fatty liver disease.

HY-125996

NR1H4 activator 1	FXR	Inflammation/Immunology
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC₅₀ value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease .

HY-50911

Turofexorate isopropyl 3 Publications Verification FXR-450; XL335; WAY-362450	FXR Autophagy	Metabolic Disease Cancer
Turofexorate isopropyl (FXR-450) is a potent, selective, and orally bioavailable *FXR* agonist with EC₅₀ of 4 nM .

HY-50911R

Turofexorate isopropyl (Standard)	FXR Autophagy	Metabolic Disease Cancer
Turofexorate isopropyl (Standard) is the analytical standard of Turofexorate isopropyl. This product is intended for research and analytical applications. Turofexorate isopropyl (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM .

HY-50108A

(E)-GW 4064	FXR	Others
(E)-GW 4064 is a *FXR* agonist .

HY-50108

GW 4064 50+ Cited Publications	FXR Autophagy	Metabolic Disease Cancer
GW 4064 is a potent *FXR* agonist with an EC₅₀ of 65 nM.

HY-N3209

Nelumol A	FXR	Inflammation/Immunology
Nelumol A is a farnesoid X receptor (FXR) agonist .

HY-159845

Lecufexor	FXR	Metabolic Disease
Lecufexor is a farnesoid X receptor (FXR) agonist .

HY-100443B

(R,R)-PX20606	FXR Autophagy	Metabolic Disease
(R,R)-PX20606 is a *FXR* agonist with EC₅₀s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

HY-100443A

trans-PX20606 2 Publications Verification trans-PX-102	FXR Autophagy	Metabolic Disease
PX20606 trans racemate (PX-102 trans racemate) is a *FXR* agonist with EC₅₀s of 32 and 34 nM for FXR in FRET and M1H assay, respectively .

HY-103704

LY2562175	FXR Autophagy	Metabolic Disease
LY2562175 is a potent and selective *FXR* agonist, with an EC₅₀ of 193 nM .

HY-160929

Linafexor CS-0159	FXR	Metabolic Disease
Linafexor (CS-0159) is an agonist for farnesoid X receptor (FXR) .

HY-N3891

Fargesone A	FXR	Inflammation/Immunology
Fargesone A is a potent and selective *FXR* agonist. Fargesone A shows anti-inflammatory activity .

HY-107418

Tropifexor 5+ Cited Publications LJN452	FXR Autophagy	Cardiovascular Disease
Tropifexor (LJN452) is a highly potent agonist of *FXR* with an EC₅₀ of 0.2 nM .

HY-N15305

Ferolin	FXR	Inflammation/Immunology
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-135400

Glyco-Obeticholic acid	FXR	Inflammation/Immunology
Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist .

HY-100443

PX20606 PX-102	FXR	Cancer
PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC₅₀ 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy .

HY-135399

Tauro-obeticholic acid	FXR	Inflammation/Immunology
Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist .

HY-135399A

Tauro-obeticholic acid sodium	FXR	Neurological Disease
Tauro-obeticholic acid sodium is an active metabolite of Obeticholic acid (HY-12222). Obeticholic acid is a potent, selective and orally active FXR agonist.

HY-109096

Nidufexor LMB763	FXR Autophagy	Inflammation/Immunology
Nidufexor (LMB763) is an orally-available farnesoid X receptor (FXR) agonist for the research of nonalcoholic steatohepatitis (NASH) .

HY-101273

BAR502	G protein-coupled Bile Acid Receptor 1 FXR Autophagy	Neurological Disease Inflammation/Immunology
BAR502 is a dual *FXR* and GPBAR1 agonist with IC₅₀ values of 2 μM and 0.4 μM, respectively.

HY-134988

EDP-305	FXR Phosphatase Cytochrome P450	Inflammation/Immunology
EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC₅₀ values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 shows a potent and consistent antifibrotic effect. EDP-305 can be used for primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH) research .

HY-169192

BAR-2227	FXR	Inflammation/Immunology
BAR-2227 (compound 3a) is a *FXR* agonist and LIFR inhibitor. BAR-2227 can be used to study liver fibrosis and inflammation .

HY-121110

Fexarene	FXR	Metabolic Disease
Fexarene is a potent and selective nonsteroidal Farnesoid X Receptor (FXR) agonist with an EC₅₀ of 36 nM. Fexarene can be used in studies of cholesterol and bile acid metabolism .

HY-12434

INT-767 5+ Cited Publications	FXR G protein-coupled Bile Acid Receptor 1 Autophagy	Cancer
INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC₅₀s of 30 and 630 nM, respectively .

HY-169792

HPG1860	FXR Aminotransferases (Transaminases)	Metabolic Disease Inflammation/Immunology
HPG1860 is an orally active, highly selective and potent *FXR* agonist, with an EC₅₀ of 18 nM (FXR-luciferase reporter assay). HPG1860 has EC₅₀ values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay). HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH) .

HY-B0172

Lithocholic acid 15+ Cited Publications 3α-Hydroxy-5β-cholanic acid	Autophagy Endogenous Metabolite Apoptosis FXR	Metabolic Disease Cancer
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a *FXR* antagonist and a PXR/SXR agonist .

HY-135400S

Glyco-obeticholic acid-d5	FXR	Inflammation/Immunology
Glyco-obeticholic acid-d₅ is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist .

HY-117918

ST-1892	FXR	Metabolic Disease Inflammation/Immunology
ST-1892 (compound 14) is a highly potent *FXR* agonist (EC₅₀=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation .

HY-135399S

Tauro-obeticholic acid-d5 sodium	FXR	Inflammation/Immunology
Tauro-obeticholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

HY-139562

BMS-986318	FXR	Metabolic Disease
BMS-986318 is a potent nonbile acid *FXR* agonist with EC₅₀s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis .

HY-111049

GSK8062	FXR	Metabolic Disease
GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels .

HY-12222

Obeticholic acid Maximum Cited Publications 82 Publications Verification INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid	FXR Autophagy	Others
Obeticholic acid (INT-747) is a potent, selective and orally active *FXR* agonist with an EC₅₀ of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy .

HY-147296

Omesdafexor MET642	FXR	Inflammation/Immunology Cancer
Omesdafexor (MET642) is an oral *FXR* agonist. Omesdafexor can improve colitis induced by adoptive T cell transfer，promote intestinal antimicrobial function, barrier function and inhibit inflammation .

HY-109197

Vonafexor 2 Publications Verification EYP001	FXR HBV	Infection
Vonafexor (EYP001) is an orally active, non-steroidal and selective *FXR* agonist. Vonafexor shows significant HBsAg reduction when combined with Peg-IFNα. Vonafexor can be used for anti-HBV research .

HY-W653920

Tauro 6-ethlchenodeoxycholic acid-d5(sodium）	Isotope-Labeled Compounds FXR	Inflammation/Immunology
Tauro 6-ethlchenodeoxycholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid (HY-135399). Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist .

HY-10912

Fexaramine 5+ Cited Publications	FXR Autophagy	Others
Fexaramine is a potent and selective *FXR* agonist with an EC₅₀ of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors .

HY-N4063

Hedragonic acid	FXR	Inflammation/Immunology
Hedragonic acid is an oleane-type triterpenoid compound, which can be isolated from the stems and roots of the southern snake vine. Hedragonic acid is a ligand and agonist for *FXR*. Hedragonic acid protected mice from liver damage caused by acetaminophen overdose and reduced liver inflammation .

HY-N10640

Alismanol M	FXR	Inflammation/Immunology
Alismanol M is a farnesoid X receptor (FXR) agonist with an EC₅₀ value of 50.25 μM. Alismanol M is a protostane-type triterpenoid that can be isolated from the rhizome of Alisma orientale. Alismanol M can be used for the research of cholestasis and nonalcoholic steatohepatitis .

HY-109083

Cilofexor 5+ Cited Publications GS-9674	FXR Autophagy	Inflammation/Immunology
Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal *FXR* agonist with an EC₅₀ of 43 nM. Cilofexor has anti-inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research .

HY-B0172R

Lithocholic acid (Standard) 15+ Cited Publications 3α-Hydroxy-5β-cholanic acid (Standard)	Reference Standards Autophagy Endogenous Metabolite Apoptosis FXR	Metabolic Disease Cancer
Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .

Cat. No.	Product Name	Target	Research Area

HY-A0248BR

Polymyxin B2 (Standard)	Reference Standards Antibiotic Bacterial	Infection
Obeticholic acid (Standard) is the analytical standard of Obeticholic acid. This product is intended for research and analytical applications. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0172

Lithocholic acid Maximum Cited Publications 16 Publications Verification 3α-Hydroxy-5β-cholanic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Autophagy Endogenous Metabolite Apoptosis FXR
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a *FXR* antagonist and a PXR/SXR agonist .

HY-B0172R

Lithocholic acid (Standard) Maximum Cited Publications 16 Publications Verification 3α-Hydroxy-5β-cholanic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Reference Standards Autophagy Endogenous Metabolite Apoptosis FXR
Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .

HY-N4294

Arjungenin	Triterpenes Classification of Application Fields Terpenoids Combretaceae Source classification Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields	FXR Insecticide
Arjungenin, a pentacyclic triterpenoid compound, is a *FXR* agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV) .

HY-N3431

Kaempferol-7-O-rhamnoside	Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Chimonanthus nitens Oliv. Plants Disease Research Fields Calycanthaceae	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)
Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure .

HY-N3209

Nelumol A	Ketones, Aldehydes, Acids Source classification Tamarindus indica L. Plants Compositae	FXR
Nelumol A is a farnesoid X receptor (FXR) agonist .

HY-N3891

Fargesone A	Source classification Magnoliaceae Lignans Yulania biondii (Pamp.) D. L. Fu Phenylpropanoids Plants	FXR
Fargesone A is a potent and selective *FXR* agonist. Fargesone A shows anti-inflammatory activity .

HY-N15305

Ferolin	Other Terpenoids Terpenoids Apiaceae Source classification Plants Ferula lapidosa Korovin	FXR
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

HY-N4063

Hedragonic acid	Triterpenes Terpenoids Source classification Celastraceae Celastrus Plants Celastrus orbiculatus Thunb.	FXR
Hedragonic acid is an oleane-type triterpenoid compound, which can be isolated from the stems and roots of the southern snake vine. Hedragonic acid is a ligand and agonist for *FXR*. Hedragonic acid protected mice from liver damage caused by acetaminophen overdose and reduced liver inflammation .

HY-N10640

Alismanol M	Triterpenes Terpenoids Alisma orinentale (Samuel.) Juz. Plants Alismataceae	FXR
Alismanol M is a farnesoid X receptor (FXR) agonist with an EC₅₀ value of 50.25 μM. Alismanol M is a protostane-type triterpenoid that can be isolated from the rhizome of Alisma orientale. Alismanol M can be used for the research of cholestasis and nonalcoholic steatohepatitis .

HY-N4294R

Arjungenin (Standard)	Triterpenes Terpenoids Combretaceae Source classification Terminalia chebula Retz. Plants	Reference Standards FXR Insecticide
Arjungenin (Standard) is the analytical standard of Arjungenin. This product is intended for research and analytical applications. Arjungenin, a pentacyclic triterpenoid compound, is a *FXR* agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV).

HY-N0910

Notoginsenoside Ft1 1 Publications Verification	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	PI3K mTOR Akt Apoptosis p38 MAPK ERK Transmembrane Glycoprotein Glutathione Reductase (GR) Estrogen Receptor/ERR Calcium Channel Ferroptosis G protein-coupled Bile Acid Receptor 1 FXR
NotoginsenosideFt1 is a saponin found in Panax notoginseng. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8 ⁺ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca ²⁺ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y₁₂ receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an *FXR* antagonist to combat obesity and insulin resistance .

Cat. No.	Product Name	Chemical Structure

HY-W653920

Tauro 6-ethlchenodeoxycholic acid-d5(sodium）
Tauro 6-ethlchenodeoxycholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid (HY-135399). Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist .

HY-12222S1

Obeticholic acid-d4
Obeticholic Acid-d₄ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC₅₀ of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy .

HY-12222S

Obeticholic acid-d5
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC₅₀ of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy .

HY-135400S

Glyco-obeticholic acid-d5
Glyco-obeticholic acid-d₅ is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist .

HY-135399S

Tauro-obeticholic acid-d5 sodium
Tauro-obeticholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

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