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Results for "

FANCD2

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Natural
Products

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126539
    UBE2T/FANCL-IN-1

    		E1/E2/E3 Enzyme Cancer
    UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .
    UBE2T/FANCL-IN-1
  • HY-153365
    I-138

    		Deubiquitinase Cancer
    I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
    I-138
  • HY-123834
    FEN1-IN-1
    Maximum Cited Publications
    6 Publications Verification

    		 FLAP ATM/ATR Cancer
    FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg 2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers .
    FEN1-IN-1
  • HY-160700
    TNG348

    		Deubiquitinase JNK Cancer
    TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [2].
    TNG348
  • HY-14520
    Tetrahydrofolic acid
    4 Publications Verification

    L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid

    		 Endogenous Metabolite Metabolic Disease
    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
    Tetrahydrofolic acid
  • HY-RS17257
    Fancd2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fancd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fancd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fancd2 Mouse Pre-designed siRNA Set A
    Fancd2 Mouse Pre-designed siRNA Set A
  • HY-RS04735
    FANCD2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FANCD2 Human Pre-designed siRNA Set A contains three designed siRNAs for FANCD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FANCD2 Human Pre-designed siRNA Set A
    FANCD2 Human Pre-designed siRNA Set A
  • HY-RS23711
    Fancd2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fancd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fancd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fancd2 Rat Pre-designed siRNA Set A
    Fancd2 Rat Pre-designed siRNA Set A
  • HY-14520A
    (6S)-Tetrahydrofolic acid

    (6S)-5,6,7,8-Tetrahydrofolic acid

    		 Endogenous Metabolite Metabolic Disease
    (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .
    (6S)-Tetrahydrofolic acid
  • HY-14520B
    Tetrahydrofolic acid trihydrochloride

    L-5,6,7,8-Tetrahydrofolic acid trihydrochloride; L-Tetrahydrofolic acid trihydrochloride

    		 Endogenous Metabolite Metabolic Disease
    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
    Tetrahydrofolic acid trihydrochloride

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