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Results for "

ETP

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110109
    ETP-45658

    		PI3K DNA-PK mTOR Cancer
    ETP-45658 is a potent PI3K inhibitor, with IC50s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK (IC50=70.6 nM) and mTOR (IC50=152.0 nM). ETP-45658 can be used for the research of cancer .
    ETP-45658
  • HY-15521
    ETP-46464
    2 Publications Verification

    		 mTOR ATM/ATR Cancer
    ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively.
    ETP-46464
  • HY-12340
    ETP-46321

    		PI3K Cancer
    ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM, respectively.
    ETP-46321
  • HY-W846144
    ETP-45835

    		MNK Cancer
    ETP-45835 is slective and potent MNK inhibitor with IC50s of 575 nM and 646 nM for MNK1 and MNK2, respectively. ETP-45835 shows little activity against 24 other kinases. ETP-45835 inhibits eIF4E Ser209 phosphorylation in cells, and has anticancer effects .
    ETP-45835
  • HY-110336
    ETP-45835 dihydrochloride

    		ERK Cancer
    D-106669 is an inhibitor of Erk2 with an IC50 value of 18.7 μM. D-106669 inhibits cell proliferation with an EC50 value of 0.9 μM .
    ETP-45835 dihydrochloride
  • HY-177477
    2,5-Epidithia-3,6-dioxopiperazine

    		Drug Derivative Cadherin β-catenin Cardiovascular Disease Cancer
    2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research .
    2,5-Epidithia-3,6-dioxopiperazine
  • HY-142102
    T988C

    (+)-T988C

    		 Others Cancer
    T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .
    T988C

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