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EGFR-IN-176

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178057
    EGFR-IN-176

    		EGFR Akt Anaplastic lymphoma kinase (ALK) Cancer
    EGFR-IN-176 is an orally active and ATP-competitive EGFR mutant inhibitor (particularly C797S-mediated EGFR triple mutant). EGFR-IN-176 demonstrates highly selective inhibition of the growth of triple-mutant cells including Ba/F3 EGFR 19del/T790M/C797S (IC50 = 0.001 nM) and Ba/F3 EGFR L858R/T790M/C797S (IC50 = 0.04 nM). EGFR-IN-176 effectively inhibits subsequent AKT signaling in Ba/F3 and PC-9 cells expressing EGFR 19del/T790M/C797S or EGFR L858R/T790M/C797S. EGFR-IN-176 selectively inhibits EGFR signaling in cell lines harboring EGFR triple mutation and shows no inhibitory effect against A431 cells that express wild-type EGFR. EGFR-IN-176 can effectively inhibit the enzymatic activity of ALK (IC50 < 0.5 nM). EGFR-IN-176 effectively inhibits tumor growth in mouse experiments and shows good anti-nonsmall cell lung cancer (NSCLC) .
    EGFR-IN-176

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